Using GalXC, Dicerna scientists attach N-acetylgalactosamine
sugars directly to the extended region of our proprietary Dicer substrate short-interfering RNA molecules, yielding multiple proprietary conjugate delivery configurations.
Lowe, Enzyme replacement therapy for mucopolysaccharidosis VI: a phase 3, randomized, double-blind, placebo-controlled, multinational study of recombinant human N-acetylgalactosamine
4sulfatase (recombinant human arylsulfataseBor rhASB) and follow-on, open-label extension study, J Pediatr 148(2006), 533-539.
Lectin histochemistry studies have shown that all cell types of spermatogenesis lineage contain mannose, N-acetylglucosamine, sialic acid, galactose, and N-acetylgalactosamine
in human, (2) and mouse.
Finally, we developed a simple method for the determination of glucuronic acid (GlcA) and N-acetylgalactosamine
(GalNAc) in purified CS by HPLC with a diode array detector (DAD).
The plant will be occupied in a phased transition with substantial manufacturing activities being tied to results of the ongoing Phase III trial for N-acetylgalactosamine
6-sulfatase (GALNS) for the treatment of Mucopolysaccharidosis IVA (MPS IVA, also known as Morquio A Syndrome).
The enzyme hydrolyzes the sulfate ester bond ofgalactose 6-sulfate in keratan sulfate and of N-acetylgalactosamine
6-sulfate in chondroitin C.
Tested carbohydrates included D-glucose, D-mannose, D-galactose, N-acetylgalactosamine
, and [alpha]lactose (Sigma).
National Institute of Advanced Industrial Science and Technology (Tokyo, Japan) has patented an enzyme which transfers N-acetylgalactosamine
to N-acetylglucosamine via a .
MPS VI (also known as Maroteaux-Lamy syndrome) is a debilitating, life-threatening genetic disease caused by a deficiency of the enzyme N-acetylgalactosamine
Viral particles bind specifically to digestive ducts (midgut, main and secondary ducts, and tubules) by carbohydrate structures with a terminal N-acetylgalactosamine
residue in an [alpha] linkage (same binding site used for recognition of human histo-blood group antigens).
100 mM each of N-acetylgalactosamine
, N-acetylglucosamine, D-galactose, D-lactose, L-fucose, D-rhamnose, and sialic acid was used in haemagglutination assay.
There are eight essential saccharides: mannose, glucose, galactose, xylose, fucose, N-acetylglucosamine, N-acetylgalactosamine
and N-acetylneuraminic acid.