CDH2

(redirected from N-Cadherin)
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CDH2

A gene on chromosome 18q11.2 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells. CDH2 functions during gastrulation and is required for establishing left-right asymmetry. At certain CNS synapses, presynaptic to postsynaptic adhesion is mediated in part by CDH2; in the hippocampus, it may regulate dendritic spine density.
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Assessment of pro-EMT transcriptional factors indeed identified expression of FoxC2, SNAIL, and ZEB1 in the vast majority of cases (100%, 89%, and 69%, respectively) that was coupled with cadherin switching from E-cadherin to N-cadherin as well as vimentin expression.
For immunofluorescence analysis, TFK-1 cells cultured on coverslips were fixed with ice-cold methanol and then stained with mouse anti-human E-cadherin, N-cadherin or Fibronectin, followed by incubation with donkey anti-mouse Alexa Fluor[R] 555 and nuclear counterstaining with DAPI.
N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling.
Immunostaining for APC and N-cadherin in control human fetal testis xenografts demonstrated Sertoli cell cytoplasm distribution around the germ cells (Figure 3I,J), similar to that in rats.
The participation of N-cadherin is crucial for key events of embryonic development, such as the growth of the neural plate, the migration of cells originating from the neural crest, mesoderm formation during gastrulation, somitogenesis, and heart tube formation (63, 64).
A typical symbol of EMT includes a striking decline in the cell-cell adhesion molecule E-cadherin expression and gain of mesenchymal markers, such as vimentin and N-cadherin, culminating in cell morphology change as well as enhanced cell motility [16].
We purchased E-cadherin antibody from BD Biosciences (San Jose, CA, USA) and N-cadherin antibody from Upstate (Billerica, MA, USA).
Following 20 minutes of cooling, the tissue sections were separately incubated with the immunohistochemical stains TTF-1, N-cadherin, CDX2, IMP3, and napsin A for 20 minutes.