For the first time, it is now possible to investigate how the formation of regular structures and the generation of mechanical forces go hand in hand during the self-assembly of myofibrils
The micrographs show mitochondria (m), myelin figures (M), well-organized myofibrils
forming intact sarcomeres (S) and a system formed by sarcoplasmic reticulum and t tubule-triads (t), areas with disorganized Z lines and thinning sarcomeres (arrows), swollen sarcoplasmic reticulum and dilated T tubes (arrowheads) and areas with disrupted sarcomeres (*).
Abbreviations: (AS) subcutaneous adipose (AV) visceral adipose (FB) white fibers (FM) muscle fibers (FI) intermediate fibers (FV) red fibers (m) myofibrils
(ms) myosepta (n) nucleus (P) skin.
Studies taking an anatomical approach tend to use immunocytochemistry or electron microscopy to evaluate sarcomere formation and myofibril
alignment as indicators of myotube maturity.
Accumulation of Ca2+ will activate calpain 3 kinase that in turn cause degradation of myofibrils
. Ubiquitin ligases will ubiquitinate the peptides and target them for degradation in the proteasome.
Shinano, "Effect of Storage Temperature on Freeze Denaturation of Carp Myofibrils
with KC1 or NaCl," Nippon Suisan Gakkaishi, vol.
Rhabdomyolysis (RM) is the destruction of skeletal muscle followed by the release of intracellular myofibrils
into the bloodstream and extracellular fluid.
Effect of different sources and levels of distillers dried grains with solubles on production on performance, serum biochemistry, bone parameters, carcass quality, and properties of myofibrils
. PhD thesis.
Contraction band necrosis describes a focal alteration in muscle architecture due to hypercontraction of myofibrils
in myocardial cells, producing dense groupings of myofibrils
interspersed between clear areas of muscle, barren of myofibrils
due to lysis .
Transmission electron microscopy showed normal mitochondria packed beside the fibers and typical, symmetric myofibrils
composed of Z lines with sarcomeres in the control and DHM-treated control mice.
While insufficient biogenesis limits ATP production and induces cell necrosis , an excessive production of mitochondria leads to disruption of myofibrils
and cardiomyocyte dysfunction .
Histopathological examination of ISO-treated rat heart showed marked myocardial necrosis, inflammatory cell infiltration, edema and vacuolization of myofibrils
. The ultrastructural sections also revealed degenerated myofibrils
, disintegrated mitochondria and swollen cristae in the rats treated with ISO-control.