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To avoid these pitfalls, it is important to recognize the presence of apocrine features and myoepithelial cells around the lobulocentric proliferations of small acini.
Low-power view showing a solid nodular pattern with compact fibrovascular cores and a p63 immunostain (d) showing continuous staining of the myoepithelial cell layer at the periphery of the involved spaces (hematoxylin-eosin, original magnifications X40 [a] X100 [b], and X200 [c]; original magnification X200 [d].
Scant myoepithelial cells may be present within the papillae or in the epithelial proliferation, but an intact myoepithelial cell layer is absent.
Microglandular adenosis is an uncommon, benign proliferative lesion characterized by small, uniform glands that infiltrate mammary stroma and characteristically lack myoepithelial cells.
Myoepithelial cells are ectodermally derived contractile cells that act as smooth muscle cells.
Combined cytologic features in epithelial cells, myoepithelial cells, and/or mesenchymal cells clearly indicate malignant neoplasm.
The p63 marker highlighted myoepithelial cells and was weakly positive in the stromal spindle cells of 1 complex sclerosing lesion/radial scar (4%; Figure 1) and was negative in all sclerosing papillomas and biopsy site stromal spindle cells.
5), there may be five alternatives: teratoid origin coupled with significant overgrowth of the myomatous elements, smooth muscle cells that migrate from the nipple during embryological life, a multipotent mesenchymal cell, angiomatous smooth muscle and myoepithelial cells.
Moderate proliferation of the fibrous connective tissue and the myoepithelial cells was observed among the proliferated acini.
This is a lesion mainly composed of malignant myoepithelial cells.
H and E stained sections revealed diffuse effacement of glandular architecture by a mixture of glandular epithelium and myoepithelial cells within a mesenchyme-like background.
Immunohistochemistry revealed that cuboidal cells were CK5/6(+), myoepithelial cells were p63(+), and tumor cells were Ki-67 (5%+), ER(+), and PR(part+).