MYOD1

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MYOD1

A gene on chromosome 11p15.4 that regulates myogenesis by encoding MyoD1, a nuclear phosphoprotein with partial homology to the myc family of oncoproteins, which binds to the enhancer sequences of the muscle-specific creatine phosphokinase gene, inhibiting DNA synthesis and cell proliferation. MyoD1 belongs to the basic helix-loop-helix (bHLH) transcription factor family and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenesis, and is involved in muscle regeneration.
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The MyoD family and myogenesis: redundancy, networks, and thresholds.
Interestingly, we found that there were similar expression patterns between miR-127-3p and three myogenic marker genes including MyoD, MyoG, and Mef2c.
We also confirmed the patterns of MyoD and Myog expression under oxidative stress condition and RSV treatment during myogenesis by immunocytochemistry.
To verify this hypothesis, we investigated the genetic polymorphisms of the MyoD, Myf5, MyoG, and Mrf4 genes in chickens and analyzed their association with muscle fibers traits.
MyoD protein differentially accumulated in fast and slow skeletal muscle fibers and required for normal fiber type balance in rodents.
We examined expression of the myoblast markers, namely MyoD, Myf5, myogenin and desmin.
The isolated BSC proliferated and further showed the MyoD, Myf5 and myogenin expression, which are known to be useful markers for proliferating satellite cells (Allen and Rankin, 1990; Cooper et al.
In subsequent experiments to validate our results, the expression of adipogenic genes such as PPAR gamma and GPDH and myogenic genes like Myf5 and MyoD were analyzed, and Oil-red-O staining was performed.
The MyoD family of bHLH transcription factors is required for the commitment and differentiation of embryonic myoblasts during development.
Proliferating myogenic precursor cells, the daughter cells of satellite cells express desmin, Myf5, MyoD and other myoblast specific markers (Cornelison and Wold, 1997).