myeloblast

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myeloblast

 [mi´ĕ-lo-blast″]
an immature cell of bone marrow, not normally found in peripheral blood; it is the most primitive precursor in the granulocytic series, which develops into the promyelocyte and eventually into a granulocyte.

my·e·lo·blast

(mī'ĕ-lō-blast),
An immature cell (10-18 mcm in diameter) in the granulocytic series, occurring normally in bone marrow, but not in the circulating blood (except in certain diseases). When stained with the usual dyes, the cytoplasm is light blue, nongranular, and variable in amount, sometimes being only a thin rim around the nucleus; the latter is deep purple-blue with finely divided, punctate, threadlike chromatin that is somewhat condensed at the periphery. A few light blue nucleoli are usually present in the nucleus, and these generally disappear as the myeloblast matures into a promyelocyte and then a myelocyte. Myeloblasts ordinarily yield a negative reaction with peroxidase.
[myelo- + G. blastos, germ]

myeloblast

(mī′ə-lə-blăst′)
n.
An immature cell of the bone marrow that is the precursor of a myelocyte.

my′e·lo·blas′tic adj.

my·e·lo·blast

(mī'ĕ-lō-blast)
An immature cell in the granulocytic series, occurring normally in bone marrow but not in the blood. When stained, the cytoplasm is light blue and variable in amount; the nucleus deep purple-blue with finely divided, punctate, threadlike chromatin. A few light blue nucleoli in the nucleus generally disappear as the myeloblast matures into a promyelocyte and then a myelocyte.
[myelo- + G. blastos, germ]

myeloblast

The bone marrow cell from which the whole series of granular white blood cells (GRANULOCYTES) derives. Up to 3% of bone marrow cells are myeloblasts.
References in periodicals archive ?
Marrow biopsy revealed 84% myeloblasts with del (15q) in all 20 analyzed cells and new del (16q) in 1 of 20 cells.
A CD34 IHC stain highlighted numerous immature cells consistent with myeloblasts which were arranged in aggregates and small sheets within the submucosa (Figure 3).
Endothelial cell activation by myeloblasts: Molecular mechanisms of leukostasis and leukemic cell dissemination.
When considered primary internal malignancies of these patients, 6 patients were diagnosed with gastrointestinal malignancy, 4--with lung cancer, 4--with breast cancer, 3--with malignant melanoma, 1--with Ewing's sarcoma, 1--with acute myeloblasts leukemia and 1 patient was diagnosed with prostatic cancer.
Bone marrow aspiration showed hypercellularity, with 45% myeloblasts, 15% promyelocytes, 7% myelocytes, 4% metamyelocytes, 1% eosinophils, 2% neutrophils, 15% lymphocytes, and 11% normoblasts.
Of 44 children with Nl, 57% (n=25) had acute lymphoblastic leukemia (ALL), 18% (n=8) had non-Hodgkins lymphoma, 9% (n=4) had acute myeloblasts leukemia (AML), 7% (n=3) had neuroblastoma, and 9% (n=4) had other solid tumors.
Consecutive phases vary, giving rise to a kinetically distinct mitotic pool in which numbers expand to include the myeloblasts, progranulocytes and myelocytes - loosely referred to as the fixed components of the microenvironment.
Acute myeloid leukemia (AML) represents a group of clonal hematopoietic stem cell disorders in which both failure to differentiate and overproliferation in the stem cell compartment result in accumulation of non-functional cells termed myeloblasts. Even though various treatment strategies such as chemotherapy, targeted therapy, allogeneic or autologous stem cell transplantation, and experimental treatment approaches were developed, the management of AML presents significant challenges, still has an unsatisfactory relapse rate (Lengfelder et al.
There was an increased number of immature neutrophils including all stages of neutrophil development except myeloblasts. Additionally, neutronphils exhibited toxic granulation, dohle bodies, and vacuolization, all of which indicated the presence of an infection.
Laboratory data showed normal hemoglobin level, thrombocytosis--1357 x [10.sup.9] /1, left shift in the differential blood count with 8% myeloblasts and 4% erythroblasts.
The tumors are composed of myeloblasts, which are immature cells of granulocytic origin.