An endopeptidase produced by leukocytes that is similar in action to that of elastase.
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Other proteases which showed an interesting trend are DDP IV targets of gliptins and proteinase 3 (PRTN3) or myeloblastin. DDP IV decreased in the normoalbuminic group and then increased during progression of DN while proteinase 3 (PRTN3) has an opposite trend with a marked increase in the normoalbuminuric and microalbuminuric group to reach a normal level in the macroalbuminuric group.
In addition to the MMPs and their relative inhibitors, two relatively new proteins emerged which are potentially involved in the complexity of DN pathogenesis: myeloblastin and its natural inhibitor Trappin-2.