myelin figure

my·e·lin fig·ure

a rolled-up or scroll-like arrangement of a lipid bilayer within a cell, superficially resembling the myelin sheath of nerves; myelin figures are observed with the electron microscope in the cytoplasm or as inclusion in mitochondria and autophagic vacuoles where they may represent artifacts of lipid fixation.
Synonym(s): myelin body
A non-specific term for concentrically layered, fingerprint-like, osmiophilic material derived from membranes and organelles—e.g., endoplasmic reticulum, seen by electron microscopy
Dermatology Odland bodies, keratinosomes A structure seen by electron microscopy in the stratum spinosum and intercellular spaces
Function Unknown. Lamellar bodies may play a role in keratinisation and are increased in lamellar ichthyosis
Hematology See Ribosomal lamellar complexes
Metabolism Lamellar bodies correspond to concentrically laminated lipoprotein- phosphatide complexes with increased uptake of H2O, ceroid, seen in autophagic vacuoles of Fabry’s disease, granular cell tumours, malignant fibrous histiocytoma, spermatocytic seminoma
Pulmonary medicine Lamellar bodies correspond to layers of membrane-bound surfactant seen by electron microscopy or high-power light microscopy, which is increased in interstitial lung diseases (e.g., desquamative interstitial pneumonitis, usual interstitial pneumonitis and diffuse alveolar damage, pulmonary alveolar proteinosis) pulmonary toxicity (methotrexate, BCNU, bleomycin, cytoxan, busulfan), type II glycogen storage disease, mucopolysacchridosis—MPS type VI—Maroteaux-Lamy syndrome, cystic fibrosis, bronchoalveolar cell carcinoma, diffuse pleural mesothelioma, papillary adenomas
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This results in cell death evocating autophagy and is characterized by the accumulation of autophagic vesicles (Figure 3(b)), extensive vacuolization (Figures 3(e) and 3(f)), degradation of membranous cellular components (Figures 3(d), 3(e), and 3(g)) that rearrange in membranous whorls called myelin figure (Figure 4), depletion of organelles, and finally complete disintegration of the cell (Figures 3(f) and 3(g)).
Menetrier et al., "Cytotoxic oxysterols induce caspase-independent myelin figure formation and caspase-dependent polar lipid accumulation," Histochemistry and Cell Biology, vol.
Myelin figures were detected (Figure 4) indicating lipid peroxidation and membrane degeneration.
Vacuoles comprising myelin figures were detected in axoplasms.
However, myelin figures, vacuoles, and sporadic electron-dense granules were detected in axoplasmic regions.
Nosotros creemos que esas estructuras electrodensas corresponden a lo que en patologia ultraestructural en el idioma ingles se conoce como 'myelin-like figures' o simplemente 'myelin figures' (23-25) y que los libros de patologia en espanol traducen como 'figuras de mielina'.
Analysis of oxidative processes and of myelin figures formation before and after the loss of mitochondrial transmembrane potential during 7-beta-hydroxycholesterol and 7-ketocholesterol-induced apoptosis: comparison with various pro-apoptotic chemicals.
In addition, TEM observation of plaques revealed certain features of autophagy in SMCs, ECs, and macrophages including the formation of myelin figures, vacuolization, and the accumulation of inclusions in the cytosol.
We observed the typical ultrastructural features of autophagy via TEM, such as vacuolization and formation of myelin figures in the nuclei of SMCs and macrophages [Figure 2]a-e.
In our study, three patterns of vacuolation were observed in the epithelial cells: one corresponded to swollen or exploded mitochondria, the most common one had the appearance of digested cellular components, and the final one contained material resembling myelin figures. These changes might be induced by the P.
The mitochondria, endoplasmic reticulum, lipid-like granules, small number of vacuoles and myelin figures appeared in the cytoplasm of the auxiliary cells (Fig.
Near the adherence zone, several vacuoles and myelin figures appeared, indicative of membrane breakdown in the cytoplasm of the auxiliary cells.