myelin figure

my·e·lin fig·ure

a rolled-up or scroll-like arrangement of a lipid bilayer within a cell, superficially resembling the myelin sheath of nerves; myelin figures are observed with the electron microscope in the cytoplasm or as inclusion in mitochondria and autophagic vacuoles where they may represent artifacts of lipid fixation.
Synonym(s): myelin body
A non-specific term for concentrically layered, fingerprint-like, osmiophilic material derived from membranes and organelles—e.g., endoplasmic reticulum, seen by electron microscopy
Dermatology Odland bodies, keratinosomes A structure seen by electron microscopy in the stratum spinosum and intercellular spaces
Function Unknown. Lamellar bodies may play a role in keratinisation and are increased in lamellar ichthyosis
Hematology See Ribosomal lamellar complexes
Metabolism Lamellar bodies correspond to concentrically laminated lipoprotein- phosphatide complexes with increased uptake of H2O, ceroid, seen in autophagic vacuoles of Fabry’s disease, granular cell tumours, malignant fibrous histiocytoma, spermatocytic seminoma
Pulmonary medicine Lamellar bodies correspond to layers of membrane-bound surfactant seen by electron microscopy or high-power light microscopy, which is increased in interstitial lung diseases (e.g., desquamative interstitial pneumonitis, usual interstitial pneumonitis and diffuse alveolar damage, pulmonary alveolar proteinosis) pulmonary toxicity (methotrexate, BCNU, bleomycin, cytoxan, busulfan), type II glycogen storage disease, mucopolysacchridosis—MPS type VI—Maroteaux-Lamy syndrome, cystic fibrosis, bronchoalveolar cell carcinoma, diffuse pleural mesothelioma, papillary adenomas
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References in periodicals archive ?
7-ketocholesterol induces protein ubiquitination, myelin figure formation, and light chain 3 processing in vascular smooth muscle cells.
In addition, TEM observation of plaques revealed certain features of autophagy in SMCs, ECs, and macrophages including the formation of myelin figures, vacuolization, and the accumulation of inclusions in the cytosol.
We observed the typical ultrastructural features of autophagy via TEM, such as vacuolization and formation of myelin figures in the nuclei of SMCs and macrophages [Figure 2]a-e.
Analysis of oxidative processes and of myelin figures formation before and after the loss of mitochondrial transmembrane potential during 7-beta-hydroxycholesterol and 7-ketocholesterol-induced apoptosis: comparison with various pro-apoptotic chemicals.
Electron microscopy of myelin figures in normal and pathological tissues.
The mitochondria, endoplasmic reticulum, lipid-like granules, small number of vacuoles and myelin figures appeared in the cytoplasm of the auxiliary cells (Fig.
Near the adherence zone, several vacuoles and myelin figures appeared, indicative of membrane breakdown in the cytoplasm of the auxiliary cells.