Delamanid inhibits the synthesis of mycolic acid
, an essential component of mycobacterial cell walls.
Isonicotinic acid hydrazide or commonly known as isoniazid (INH) is one of the most significant anti-TB first-line drugs, which impede mycolic acid
synthesis to kill actively growing intracellular and extracellular tubercle bacilli .
The team hypothesises that similarly structured beta lactones could "mask" themselves as mycolic acid
to enter the mycolic acid
metabolic pathways and then block the decisive enzymes.
Isonicotinoyl acyl radical which formed, then reacts with NADH to form INH-NADH complex in the enzyme active site of enoly ACP reductase (InhA) and 2-ketoacyl ACP synthase (KasA), then impede the activity of two enzymes in the biosynthesis of mycolic acid
, the main component in the cell wall of mycobacteria [5,6,7].
Mycobacteria are referred to as AFB for the complex that forms during the histological staining process between the mycolic acid
in the mycobacterial cell wall and dye, which is resistant to the decolorizing mineral acid.
Furthermore, these observations could also be due to the fact that mycobacteria have unique cell envelope known as mycomembrane comprising mycolic acids
which are known to govern pathogenicity of mycobacteria and that iron deprivation may possibly affect mycolic acid
synthesis as well.
"Thanks to World Community Grid's massive computational power, we can study many different mycolic acid
structures instead of just a few," says Dr.
The emergence of lipids as T cell antigens presented by CD1 molecules was only established 5 years later by the discovery of the antigenic properties of mycolic acid
mucogeniucm exhibits two widely separated sets of mycolic acid
Microbes use the organic matters as their energy source and degrade them into a less toxic form, but most of the system suffers from the excessive growth of unwanted mycolic acid
containing filamentous bacteria or mycolata , which lead to the formation of brown and sticky foam .
 developed a new effective mycolic acid
precipitation method for the distinction between mycobacteria and other mycolic acid-containing taxa.
Several new techniques have been developed to improve the diagnosis of tuberculosis, including newer radiometric methods, DNA probes, chromatography of mycolic acid
, polymerase chain reaction (PCR) and serological tests.