Such pores do exist, both in the form of naturally occurring or slightly modified protein porins (such as human hemolysin or Mycobacterium smegmatis
porin A), or various controlled synthesis solid state materials including metals, metal alloys, and carbon nanotubes.
albicans and not only reveals deeper insights into the anticandidal mechanisms but also provided sufficient clues to decipher its antimycobacterial potential against the surrogate model of MTB, Mycobacterium smegmatis
. We explored that MB is an efficient antimicrobial agent against C.
phlei (10,12) and Mycobacterium smegmatis
(13) rich in proteins had immunostimulating activity.
(25) Studies carried out earlier with mutant strains showed that over-expression of hspX gene slows the growth of both MTB and Mycobacterium smegmatis
(2) and probably pushes the bacteria to enter dormant state.
Hesper Rego, Ph.D., of Yale University School of Medicine, and their coworkers first studied Mycobacterium smegmatis
, a close relative of Mycobacterium tuberculosis (Mtb), the microbe that causes TB.
Proteoliposomes from Mycobacterium smegmatis
induce immune crossreactivity against Mycobacterium tuberculosis antigens in mice.
This group is subdivided into six different complexes based on genetic relatedness and pigmentation: Mycobacterium fortuitum, Mycobacterium chelonae/abscessus, Mycobacterium mucogenicum, Mycobacterium smegmatis
, earlypigmentingRGM, and nonpigmented RGM [6,7].
[28.] Engelhardt H, Heinz C, Niederweis M (2002) A tetrameric porin limits the cell wall permeability of Mycobacterium smegmatis
. J Biol Chem 277: 37567-37572.
coli; in case of Mycobacterium smegmatis
and M.fortuitum corresponding time intervals were 0, 6, 12, 24, 48, and 72 h.
Approximately 80% of disease in humans due to RGM is caused by the nonpigmented Mycobacterium chelonae, Mycobacterium abscessus, and Mycobacterium fortuitum, with the remainder caused by RGM of the pigmented Mycobacterium smegmatis
group and other rarely pathogenic groups (1) (Table).
Washington, July 22 ( ANI ): Microbiologists has find the mechanisms by which the aerobic soil microbe Mycobacterium smegmatis
is able to persist for extreme lengths of time in the absence, or near-absence, of oxygen which might develop a revolutionary class of antibiotics to tackle TB.
Barletta, "Mycobacterium smegmatis
L-alanine dehydrogenase (Ald) is required for proficient utilization of alanine as a sole nitrogen source and sustained anaerobic growth," Journal of Bacteriology, vol.