Mycobacterium avium complex

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Mycobacterium avium complex

A group of genetically related mycobacteria including M avium, M intracellulare and M avium subspecies paratuberculosis.

Mycobacterium avium complex

Abbreviation: MAC, MAI
An atypical mycobacterium that causes systemic bacterial infection in patients with advanced immunosuppression, esp. those with AIDS. It occasionally causes lung infections in patients with chronic obstructive lung disease. Synonym: Mycobacterium avium-intracellulare complex


MAC infection in AIDS patients can cause fatigue, fever, weight loss, cachexia, pancytopenia, and death.


Multiple antimicrobial agents, given at the same time and for long courses, are required to treat MAC. Combination therapy may include a macrolide with drugs such as rifabutin, ethambutol, ciprofloxacin, amikacin, and/or clofazimine.

See also: complex
References in periodicals archive ?
A prospective, randomized trial examining the efficacy and safety of clarithromycin in combination with ethambutol, rifabutin, or both for the treatment of disseminated Mycobacterium avium complex disease in persons with acquired immunodeficiency syndrome.
Hot tub lung is believed to be a hypersensitivity pneumonitis caused by exposure to aerosolized Mycobacterium avium complex (MAC) and other nontuberculous mycobacteria (NTM) predisposed to grow in indoor hot tubs, enclosed swimming pools, spas, and therapy pools.
Prophylaxis against Mycobacterium avium complex recommendations were followed by 83% and 75% of those in the risk behavior and ver tical-transmission groups, respectively.
Species identification of Mycobacterium avium complex isolates by a variety of molecular techniques.
Hypersensitivity pneumonitis associated with Mycobacterium avium complex and hot tub use.
Called Klearsen Respiratory Inhalation Therapy, it may be the first nonantibiotic therapy specifically to remedy the aquatic affliction mycobacterium avium complex, or MAC.

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