Mycobacterium avium complex

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Mycobacterium avium complex

A group of genetically related mycobacteria including M avium, M intracellulare and M avium subspecies paratuberculosis.

Mycobacterium avium complex

Abbreviation: MAC, MAI

An atypical mycobacterium that causes systemic bacterial infection in patients with advanced immunosuppression, esp. those with AIDS. It occasionally causes lung infections in patients with chronic obstructive lung disease. Synonym: Mycobacterium avium-intracellulare complex

Symptoms

MAC infection in AIDS patients can cause fatigue, fever, weight loss, cachexia, pancytopenia, and death.

Treatment

Multiple antimicrobial agents, given at the same time and for long courses, are required to treat MAC. Combination therapy may include a macrolide with drugs such as rifabutin, ethambutol, ciprofloxacin, amikacin, and/or clofazimine.

See also: complex

References in periodicals archive ?

Molecular phylogeny of the Mycobacterium avium complex demonstrates clinically meaningful divisions.

Mycobacterium avium in Community and Household Water, Suburban Philadelphia, Pennsylvania, USA, 2010-2012

A prospective, randomized trial examining the efficacy and safety of clarithromycin in combination with ethambutol, rifabutin, or both for the treatment of disseminated Mycobacterium avium complex disease in persons with acquired immunodeficiency syndrome.

Hemophagocytic lymphohistiocytosis (HLH): Elusive diagnosis of disseminated Mycobacterium avium complex infection

Two cases of long lasting bacteremia due to Mycobacterium avium complex despite new macrolides-containing regimens in patients with acquired immunodeficiency syndrome.

Clinical and Laboratory Characteristics of Patients with Nontuberculous Mycobacterium Bloodstream Infection in a Tertiary Referral Hospital in Beijing, China

Sources of Mycobacterium avium complex infection resulting in human diseases.

Urinary mycobacterium avium presenting as sterile pyuria

Smith, "Mycobacterium avium complex parotid lymphadenitis: successful therapy with clarithromycin and ethambutol," Pediatric Infectious Disease Journal, vol.

Medical management for the treatment of nontuberculous mycobacteria infection of the parotid gland: avoiding surgery may be possible

Mycobacterium avium complex, an emerging pathogen in Massachusetts.

Epidemiology and ecology of opportunistic premise plumbing pathogens: Legionella pneumophila, Mycobacterium avium, and pseudomonas aeruginosa

Mycobacterium avium complex: An unusual cause of peritonitis in patients undergoing continuous ambulatory peritoneal dialysis.

Atypical mycobacterial infections of peritoneal dialysis catheter exit sites--a Louisiana issue

Intracellular activities of roxithromycin used alone and in association with other drugs against Mycobacterium avium complex in human macrophages.

Determination of the activity of standard anti-tuberculosis drugs against intramacrophage Mycobacterium tuberculosis, in vitro: MGIT 960 as a viable alternative for BACTEC 460

While improved antiretroviral treatment has led to a decrease in the incidence of disseminated Mycobacterium avium complex infections in AIDS patients, the rate of pulmonary NTM infections is increasing [4].

Nontuberculous mycobacteria in Guadeloupe, Martinique, and French Guiana from 1994 to 2012

Control strain: Known strains of Mycobacterium avium complex (MAC), M.

Pulmonary infections due to mycobacterium tuberculosis & non-tuberculosis mycobacteria in HIV seropositive patients

Mycobacterial Mycobacterium avium complex species Method of diagnosis Bone marrow showed non-caseating and laboratory granulomatosis.

Mycobacterium tuberculosis-associated hemophagocytic syndrome in systemic lupus erythematosus / A case report: sistemik lupus eritematozde mycobacterium tuberculosis ile iliskili hemofagositik sendrom: olgu sunumu