Mycobacterium avium complex


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Mycobacterium avium complex

A group of genetically related mycobacteria including M avium, M intracellulare and M avium subspecies paratuberculosis.

Mycobacterium avium complex

Abbreviation: MAC, MAI
An atypical mycobacterium that causes systemic bacterial infection in patients with advanced immunosuppression, esp. those with AIDS. It occasionally causes lung infections in patients with chronic obstructive lung disease. Synonym: Mycobacterium avium-intracellulare complex

Symptoms

MAC infection in AIDS patients can cause fatigue, fever, weight loss, cachexia, pancytopenia, and death.

Treatment

Multiple antimicrobial agents, given at the same time and for long courses, are required to treat MAC. Combination therapy may include a macrolide with drugs such as rifabutin, ethambutol, ciprofloxacin, amikacin, and/or clofazimine.

See also: complex
References in periodicals archive ?
Molecular phylogeny of the Mycobacterium avium complex demonstrates clinically meaningful divisions.
A prospective, randomized trial examining the efficacy and safety of clarithromycin in combination with ethambutol, rifabutin, or both for the treatment of disseminated Mycobacterium avium complex disease in persons with acquired immunodeficiency syndrome.
Two cases of long lasting bacteremia due to Mycobacterium avium complex despite new macrolides-containing regimens in patients with acquired immunodeficiency syndrome.
Sources of Mycobacterium avium complex infection resulting in human diseases.
Smith, "Mycobacterium avium complex parotid lymphadenitis: successful therapy with clarithromycin and ethambutol," Pediatric Infectious Disease Journal, vol.
Mycobacterium avium complex pulmonary disease in patients without HIV infection.
Mycobacterium avium complex: An unusual cause of peritonitis in patients undergoing continuous ambulatory peritoneal dialysis.
Intracellular activities of roxithromycin used alone and in association with other drugs against Mycobacterium avium complex in human macrophages.
While improved antiretroviral treatment has led to a decrease in the incidence of disseminated Mycobacterium avium complex infections in AIDS patients, the rate of pulmonary NTM infections is increasing [4].

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