Soria, "Exomics and immunogenics: bridging mutational load
and immune checkpoints efficacy," Oncoimmunology, vol.
Citation: Keiichiro Suzuki et al.; "Targeted Gene Correction Minimally Impacts Whole-Genome Mutational Load
in Human-Disease-Specific Induced Pluripotent Stem Cell Clones"; Cell Stem Cell, 2014; 15 (1): 31 DOI: 10.1016/j.stem.2014.06.016
The evidence for high nucleotide polymorphism in the Pacific oyster is interesting in light of recent experimental evidence for a high mutational load
in this species (Launey & Hedgecock 2001, Bucklin 2002).
At the a = 0 line (no asexuality), a sharp threshold of mutational load
and equilibrium inbreeding depression is observed, as in Lande et al.
While some factors like tumor PD-L1 (programmed cell death ligand 1) expression, high mutational load
, and T-cell infiltration may help select the best responders, the fact that some patients lacking these factors still respond suggests that we cannot yet exclude patients based upon these factors.
The effects of selection in the gametophyte stage on mutational load
. Evolution 46:703-720.
Given this emerging evidence for intratumor heterogeneity in somatic mutational status between sites of disease and for the risks associated with biopsying multiple sites of disease (6, 14), it is critical to determine how less-invasive techniques can be established to profile a tumor's somatic mutational load
more rapidly and to track its evolution over time.
Specifically, when the rate of population growth is assumed to be a function of deleterious mutational load
, the probability of extinction of selfing populations is predicted to be greater than that of outcrossing populations.
This novel metric, "mutational load
distribution analysis," is based on precise quantification of a subset of KRAS and TP53 (tumor protein 53) alleles and can effectively discriminate between normal pancreatic tissue and pancreatic tumors (34).
Edison Liu: First will be the conceptual advance in understanding the detailed genetic mutations and mutational load
of human cancers.
This results in a lower mutational load
in a gametes than in A gametes, an effect that is intensified when either allele is a rare recessive.