genetic load

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Related to Mutational load: Genetic burden

ge·net·ic load

the aggregate of more or less harmful genes that are carried, mostly hidden, in the genome that may be transmitted to descendants and cause morbidity and disease; in classic genetic dynamics, genetic load may be seen as undischarged genetic debts that result from previous mutations, each of which is supposed to exact an average number of lethal equivalents dependent only on the pattern of inheritance, regardless of how mild or severe the phenotype may be.

genetic load

n.
1. The relative difference between the theoretically most fit genotype within a population and the average genotype.
2. The aggregate of deleterious genes that are carried, mostly hidden, in the genomes of a population and may be transmitted to descendants.

ge·net·ic load

(jĕ-net'ik lōd)
The aggregate of more or less harmful genes that are carried, mostly hidden, in the genome and may be transmitted to descendants and cause disease.

genetic load

The totality of abnormalities caused in each generation by defective genetic material carried in the human gene pool.

genetic load

a measurement of the amount of deleterious genes in a population, calculated as the average number of lethal equivalents per individual.
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References in periodicals archive ?
Soria, "Exomics and immunogenics: bridging mutational load and immune checkpoints efficacy," Oncoimmunology, vol.
Citation: Keiichiro Suzuki et al.; "Targeted Gene Correction Minimally Impacts Whole-Genome Mutational Load in Human-Disease-Specific Induced Pluripotent Stem Cell Clones"; Cell Stem Cell, 2014; 15 (1): 31 DOI: 10.1016/j.stem.2014.06.016
The evidence for high nucleotide polymorphism in the Pacific oyster is interesting in light of recent experimental evidence for a high mutational load in this species (Launey & Hedgecock 2001, Bucklin 2002).
At the a = 0 line (no asexuality), a sharp threshold of mutational load and equilibrium inbreeding depression is observed, as in Lande et al.
While some factors like tumor PD-L1 (programmed cell death ligand 1) expression, high mutational load, and T-cell infiltration may help select the best responders, the fact that some patients lacking these factors still respond suggests that we cannot yet exclude patients based upon these factors.
The effects of selection in the gametophyte stage on mutational load. Evolution 46:703-720.
Given this emerging evidence for intratumor heterogeneity in somatic mutational status between sites of disease and for the risks associated with biopsying multiple sites of disease (6, 14), it is critical to determine how less-invasive techniques can be established to profile a tumor's somatic mutational load more rapidly and to track its evolution over time.
Specifically, when the rate of population growth is assumed to be a function of deleterious mutational load, the probability of extinction of selfing populations is predicted to be greater than that of outcrossing populations.
This novel metric, "mutational load distribution analysis," is based on precise quantification of a subset of KRAS and TP53 (tumor protein 53) alleles and can effectively discriminate between normal pancreatic tissue and pancreatic tumors (34).
Edison Liu: First will be the conceptual advance in understanding the detailed genetic mutations and mutational load of human cancers.
This results in a lower mutational load in a gametes than in A gametes, an effect that is intensified when either allele is a rare recessive.