genetic load

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ge·net·ic load

the aggregate of more or less harmful genes that are carried, mostly hidden, in the genome that may be transmitted to descendants and cause morbidity and disease; in classic genetic dynamics, genetic load may be seen as undischarged genetic debts that result from previous mutations, each of which is supposed to exact an average number of lethal equivalents dependent only on the pattern of inheritance, regardless of how mild or severe the phenotype may be.

Farlex Partner Medical Dictionary © Farlex 2012

genetic load

1. The relative difference between the theoretically most fit genotype within a population and the average genotype.

2. The aggregate of deleterious genes that are carried, mostly hidden, in the genomes of a population and may be transmitted to descendants.

ge·net·ic load

(jĕ-net'ik lōd)

The aggregate of more or less harmful genes that are carried, mostly hidden, in the genome and may be transmitted to descendants and cause disease.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

genetic load

The totality of abnormalities caused in each generation by defective genetic material carried in the human gene pool.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

genetic load

a measurement of the amount of deleterious genes in a population, calculated as the average number of lethal equivalents per individual.

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

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lethal equivalent

References in periodicals archive ?

MERRF Cybrid Presents High Level of mtDNA Mutation Load, ROS Expression and Oxidative Damage, and Reduced Mitochondrial Bioenergetics.

Mitochondrial Transfer from Wharton's Jelly Mesenchymal Stem Cell to MERRF Cybrid Reduces Oxidative Stress and Improves Mitochondrial Bioenergetics

After interruption of anti-EGFR therapy; the KRAS mutation load distinctly declined and remained below the limit of detection across subsequent lines of treatment.

Clinical Application of Liquid Biopsy in Targeted Therapy of Metastatic Colorectal Cancer

To determine whether the cancer mutation load is correlated with the expression levels of NEIL1, NEIL2, and NEIL3 in human cancer, mRNA expression data and somatic mutation data for 13 cancer types were obtained from the TCGA database.

Abnormal Expressions of DNA Glycosylase Genes NEIL1, NEIL2, and NEIL3 Are Associated with Somatic Mutation Loads in Human Cancer

The prognosis of MELAS patients depends on the location of genetic mutations, mutation load, and the onset of disease and interventions.

Progress in Diagnosing Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes

We developed a method to accurately quantify the mutant load in mtDNA; using this quantitative DHPLC analysis method, we measured the levels of heteroplasmy in several DNA samples with known mutation loads.

Quantitative mitochondrial DNA mutation analysis by denaturing HPLC

In such situations, the terminal mutation load of asexual populations is equivalent to that of infinite populations, and the elimination of clones by Kondrashov's mechanism requires mutation rates greater than 1.0 per genome per generation (Howard 1994).

The maintenance of sex by parasitism and mutation: accumulation under epistatic fitness functions

GABRIEL 1990 Mutation load and the survival of small populations Evolution 44:1725-1737.

Mutation and extinction: the role of variable mutational effects synergistic epistasis, beneficial mutations, and degree of outcrossing

This result thus demonstrated that it was possible to maintain very high lethal as well as sublethal mutation loads and inbreeding depression, even in the face of substantial self-fertilization.

Inbreeding depression under joint selfing, outcrossing, and asexuality

Therefore, experimental studies on epistasis between deleterious mutations have been based on indirect estimates of the individual mutation load, by assuming a relationship between mutation number and some other experimental variable that can be known more accurately.

Test of interaction between genetic markers that affect fitness in Aspergillus niger

Following the classic Haldane principle (1937), the population genomic mutation load only depends on the fitness mutation rate.

The rate and effects distribution of viability mutation in Drosophila: minimum distance estimation

I also calculated and recorded average number of deleterious mutations carried in adult plants (after selection) by genotype at the special locus (AA, Aa, aa), average number of deleterious mutations by gamete type (A, a), and overall mutation load and inbreeding depression every 20 generations during the course of each run.

Evolution of a beneficial allele under partial selfing and inbreeding depression

(1963) have shown that the extent to which drift causes the expressed mutation load to increase is a function of s, the selective disadvantage of a mutation.

Severe inbreeding depression and rapid fitness rebound in the butterfly Bicyclus anynana (Satyridae)

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