genetic load

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ge·net·ic load

the aggregate of more or less harmful genes that are carried, mostly hidden, in the genome that may be transmitted to descendants and cause morbidity and disease; in classic genetic dynamics, genetic load may be seen as undischarged genetic debts that result from previous mutations, each of which is supposed to exact an average number of lethal equivalents dependent only on the pattern of inheritance, regardless of how mild or severe the phenotype may be.

genetic load

n.
1. The relative difference between the theoretically most fit genotype within a population and the average genotype.
2. The aggregate of deleterious genes that are carried, mostly hidden, in the genomes of a population and may be transmitted to descendants.

ge·net·ic load

(jĕ-net'ik lōd)
The aggregate of more or less harmful genes that are carried, mostly hidden, in the genome and may be transmitted to descendants and cause disease.

genetic load

The totality of abnormalities caused in each generation by defective genetic material carried in the human gene pool.

genetic load

a measurement of the amount of deleterious genes in a population, calculated as the average number of lethal equivalents per individual.
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References in periodicals archive ?
MERRF Cybrid Presents High Level of mtDNA Mutation Load, ROS Expression and Oxidative Damage, and Reduced Mitochondrial Bioenergetics.
After interruption of anti-EGFR therapy; the KRAS mutation load distinctly declined and remained below the limit of detection across subsequent lines of treatment.
To determine whether the cancer mutation load is correlated with the expression levels of NEIL1, NEIL2, and NEIL3 in human cancer, mRNA expression data and somatic mutation data for 13 cancer types were obtained from the TCGA database.
The prognosis of MELAS patients depends on the location of genetic mutations, mutation load, and the onset of disease and interventions.
We developed a method to accurately quantify the mutant load in mtDNA; using this quantitative DHPLC analysis method, we measured the levels of heteroplasmy in several DNA samples with known mutation loads.
In such situations, the terminal mutation load of asexual populations is equivalent to that of infinite populations, and the elimination of clones by Kondrashov's mechanism requires mutation rates greater than 1.0 per genome per generation (Howard 1994).
This result thus demonstrated that it was possible to maintain very high lethal as well as sublethal mutation loads and inbreeding depression, even in the face of substantial self-fertilization.
Therefore, experimental studies on epistasis between deleterious mutations have been based on indirect estimates of the individual mutation load, by assuming a relationship between mutation number and some other experimental variable that can be known more accurately.
Following the classic Haldane principle (1937), the population genomic mutation load only depends on the fitness mutation rate.
I also calculated and recorded average number of deleterious mutations carried in adult plants (after selection) by genotype at the special locus (AA, Aa, aa), average number of deleterious mutations by gamete type (A, a), and overall mutation load and inbreeding depression every 20 generations during the course of each run.
(1963) have shown that the extent to which drift causes the expressed mutation load to increase is a function of s, the selective disadvantage of a mutation.