MUTYH

(redirected from MutY homologue)

MUTYH

An excision repair enzyme involved in repairing one of the most frequent and stable forms of nucleotide damage, 8-oxo-7,8-dihydro-2’-deoxyguanosine, which readily misrepairs with adenosine. This misrepair leads to a G:C to T:A transversion mutation. MUTYH excises the misincoporated adenine and suppresses mutations caused by reactive oxygen species. It can also can excise 2-hydroxyadenine, which is generated by oxidation of dATP in the nucleotide pool and incorporated opposite guanine in a different template.