A nitrogen mustard derivative which binds to DNA, crosslinking both strands to prevent its replication.

Global village
Mechlorethamine was first developed as a chemical weapon.

A nitrogen mustard alkylating agent used for managing lymphomas; part of MOPP.
Adverse effects
Nausea, vomiting, marrow suppression, skin vesiculation at injection site.


Chlormethine, a drug used to treat some cases of HODGKIN'S DISEASE. It is very toxic and is liable to cause severe vomiting.
References in periodicals archive ?
The ongoing demolition and remediation at the former Burger power plant is a positive signal and will position the site well for redevelopment should PTTGC America decide to move forward," said David Mustine, JobsOhio Senior Advisor.
Long term follow up of topical mustine treatment for cutaneous langerhans cell histiocytosis.
Kasich, Solon Vice Mayor Edward Kraus and Jobs Ohio Managing Director David Mustine.
"Recycling saves energy, conserves our natural resources, and extends the life of a landfill, all while creating jobs," said David Mustine, Director of the Ohio DNR.
(15,19) When treatment is necessary, a minimalist approach should be selected--one that includes a topical steroid, topical mustine (nitrogen mustard, an alkylating agent), and possibly steroid injections.