Mustargen

Mustargen

 [mus´ter-jen]
trademark for a preparation of mechlorethamine hydrochloride, an antineoplastic agent.

Mustargen

(mŭs′tər-jən)
A trademark for the drug mechlorethamine hydrochloride.

Mustargen

a trademark for an antineoplastic (mechlorethamine hydrochloride).

mechlorethamine

A nitrogen mustard derivative which binds to DNA, crosslinking both strands to prevent its replication.

Global village
Mechlorethamine was first developed as a chemical weapon.

Oncology
A nitrogen mustard alkylating agent used for managing lymphomas; part of MOPP.
 
Adverse effects
Nausea, vomiting, marrow suppression, skin vesiculation at injection site.
References in periodicals archive ?
The drug that started it all, Mustargen, became a key element in the revolutionary MOPP (Mustargen, Oncovin, procarbazine, and prednisone) combination chemotherapy regimen pioneered by Dr.
Initial observations regarding Mustargen were made during World War I, "when thousands were gassed," leading to recognition of profound lymph and bone marrow suppression in exposed soldiers and speculation that the agent might have therapeutic utility in diseases characterized by lymphoid and myeloid proliferation, said Dr.