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An alkaloid extracted from the poison mushroom Amanita muscaria; selectively stimulates receptors for γ-aminobutyric acid (GABA) and is used as a molecular probe to study GABA receptors; a potent CNS depressant, muscimol inhibits motor function; exposure can lead to psychosis; 3-aminometnyl-3-hydroxyisoxazole.
References in periodicals archive ?
Inoue H, Yoshida T, Kishi T: Determination of muscimol and ibotenic acid
According to literature, GABA[sub]AR selective agonist muscimol (MUS) can inhibit NMDAR-induced neurotoxicity in primary cell cultures,[sup][9] it can also reduce cell death in global or focal cerebral ischemia.
After ketamine microinfusion with or without muscimol, the rodents underwent behavioral testing to assess the degree of depression or anxiety they displayed in situations of stress.
5 nmol/100nl muscimol are shown in figure 1 and the maximum MAP and HR changes are shown in figure 2.
18: Non-classic bioisosteric relationship between Gamma-aminobutyric acid (GABA) and muscimol.
Effects of muscimol applied to the basolateral amygdala on acquisition and expression of contextual fear conditioning in rats.
Son importantes intermediarios sinteticos ya que se pueden considerar como aminoalcoholes enmascarados, los cuales hacen parte de una amplia variedad de compuestos biologicamente activos, tales como el acido ibotenico, el muscimol y la acivicina; asimismo tras algunas transformaciones simples pueden dar origen a iminas ciclicas, lactamas, [beta]-hidroxicetonas, nitrilos y cetonas [alfa], [beta]-insaturadas (6).
Two primary compounds, ibotenic acid and muscimol, are known to occur in pharmacologically active levels and are partially, if not entirely, responsible for Amanita muscaria's psychoactive effects.
The researchers used the GABAergic modulators picrotoxin and mucimol to test the sleep promoting effects of withania and found that the herb's root extract induced sleep promoting effects by involving GABAergic modulation, which was antagonised by picrotoxin but potentiated by muscimol (Kumar 2008).
A] agonist muscimol to preferentially activate an inward current, while baclofen had a weak or variable response.
In the same experiments, however, injections of muscimol (a GABA agonist) in the posterior hypothalamus transiently recovered sleep, suggesting that the sleep-promoting role of the anterior hypothalamus is dependent on inhibition of posterior hypothalamic histaminergic awakening neurons.