QVM149 combines comprehensive bronchodilation of indacaterol acetate (a LABA [long-acting beta agonist]) and glycopyrronium bromide (a LAMA [long-acting muscarinic receptor antagonists
) with mometasone furoate (an inhaled corticosteroid) in a precise once-daily formulation delivered in a dry-powder inhaler device.
The affinities of atropine, scopolamine, biperiden and pirenzepine, the main muscarinic receptor antagonists are shown in Table 2.
Muscarinic receptor antagonists: effects on pulmonary function.
Traditionally, muscarinic receptor antagonists have been contraindicated in patients with BPH due to fears of urinary retention.
Oxybutynin, a non-selective muscarinic receptor antagonist, and darifenacin, selective for M[sub.3] receptors, have been demonstrated to modulate bladder afferent activity, both in C fibres and Adelta fibres.[sup.5] Such an effect may be an important mechanism of action for antimuscarinics.
Pharmacological basis for functional selectivity of partial muscarinic receptor antagonists
Articles integrate molecular and neurochemical approaches to behavior applications in animal models and clinical applications with cutting-edge research in such topics as pharmacologic models (muscarinic receptor antagonists
and nicotinic receptors in rats, animal models and the cognitive effects of ethanol, toxocologic models (lead exposure, methylmercury, PCBs, MPTP), mouse genetic models (transgenic mouse models of amyloid deposition, cholinergic receptor knockout mice, mutant mice) and model applications and future developments (pharmacology in aging macaques, traumatic brain injury, models using complementary species and cognition models and drug discovery).
Muscarinic receptor antagonists
for overactive bladder.
Atropine, a nonspecific muscarinic receptor antagonist
, is a potent cycloplegic and was initially used for myopia control on the premise that excessive ocular accommodation was the cause of myopia progression.