quaternary structure

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qua·ter·nar·y struc·ture

the three-dimensional arrangement and constitution of a multimeric (that is, containing more than one biopolymer) macromolecule; for example, the α2β2 tetramer of hemoglobin A.

quaternary structure

n.
The three-dimensional arrangement of the macromolecules making up a functional unit, such as that formed by four globin protein molecules to make hemoglobin or by histones interacting with DNA to make a nucleosome.
References in periodicals archive ?
In mammals, the mTOR kinase interacts with several proteins to form two functionally distinct multiprotein complexes, namely, mTOR Complex 1 (mTORC1) and mTOR Complex 2 (mTORC2).
mTOR interacts with different proteins and forms two structurally and functionally distinct multiprotein complexes: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) [16].
A group of scientists from the European Molecular Biology Laboratory (EMBL), in Heidelberg, Germany, and colleagues in Britain, France, Switzerland and Sweden have called their discovery "the first fully automated pipeline for the production of multiprotein complexes", or ACEMBL, said a European Commission note.
This enlarges and extends the fine-tuning (and purposeful design) that many researchers find in physics and cosmology (e.g., the laws of nature, physical constants, amount of matter in the universe, etc.) to include the properties of elements and chemicals (including biochemicals like DNA), the origin of life, cells, multiprotein complexes, molecular machines, and the basic divisions of the biological world from kingdoms down "at least to the level of the major classes of vertebrates, perhaps further." The "edge of evolution"--the line that separates what unguided evolutionary processes can do from what they cannot do--lies somewhere between the major classes of vertebrates and individual species.
Serious Color Care is free of animal products and contains potent antioxidants such as melanin, heliogenol and vitamins C and E as well as multiprotein complexes and certified organic botanicals to prevent sun fading and oxidation.
The ability of SOX proteins to bind in close proximity to other transcription factors and to distort DNA suggests that they can act as "architectural proteins," possibly by promoting the assembly of biologically active multiprotein complexes. These complexes, in turn, mediate the interactions between distant chromatin domains, bringing together promoter/enhancer regions, finally assembling the "chromatin hubs" that control gene expression regulation [15-17].
TJs, composed of large multiprotein complexes, seal the gaps between biological barriers [4].
In the BBB, TJs are composed of large multiprotein complexes that mediate tight intercellular contacts among adjacent cells and play a critical role in maintaining BBB function by improving the barrier function at the endothelial level [29].
Inflammasomes, multiprotein complexes consisting of proinflammatory caspase, nucleotide-binding oligomerization domain-like receptor family members containing pyrin domain (NLRP), and the adaptor molecule apoptosisassociated speck-like protein, have proved their vital role in the process of the generation of the IL-1[beta] [10, 11].

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