Asymptomatic children with multiple endocrine neoplasia type 1
mutations may harbor nonfunctioning pancreatic neuroendocrine tumors.
Multiple endocrine neoplasia type 1
gene maps to chromosome 11 and is lost in insulinoma.
MEN-1: Multiple endocrine neoplasia type 1
, NECT: Neuroendocrine tumor, GHRH: Growth hormone releasing hormone, GH: Growth hormone, IGF-1: Insulin like growth factor.
Identification of the multiple endocrine neoplasia type 1
Friedman, E., Larsson, C., Amorosi, A., Brandi, M.L., Bale, A., Metz, D., Jensen, R.T., Skarulis, M., Eastman, R.C., Nieman, L., Norton, J.A., Marx, S.J., "Multiple endocrine neoplasia type 1
: Pathology, pathophysiology, and differential diagnosis," in The Parathyroids, ed.
Burgess, "Multiple endocrine neoplasia type 1
(MEN 1) is associated with an increased prevalence of diabetes mellitus and impaired fasting glucose," Clinical Endocrinology, vol.
Is the multiple endocrine neoplasia type 1
gene a suppressor for fundic argyrophil tumors in the Zollinger-Ellison syndrome?
Familial isoloated primary parathyroidism- a multiple endocrine neoplasia type 1
variant Eur J Endocrinol 2001; 145: 155-60.
Germline inactivating mutations of MEN1 gene are the main cause of multiple endocrine neoplasia type 1
(MEN1), a syndrome characterized by tumors in the pituitary gland, the parathyroid glands, and the enteropancreatic neuroendocrine tissues.
(8) However, previously reported cases of a concomitant parathyroid adenoma and a leiomyoma occurred only in patients with multiple endocrine neoplasia type 1
. (9) Moreover, there has not been any documented case of a concomitant parathyroid adenoma and a laryngeal vascular leiomyoma.
Brandi, M.L., Marx, S.J., Aurbach, G.D., and Fitzpatrick, L.A., "Familial Multiple Endocrine Neoplasia Type 1
: A new look at pathophysiology." Endocrine Reviews, vol.
(8) Similar to multiple endocrine neoplasia type 1
(MEN1) syndrome, patients with VHL disease can be associated with precursor lesions including ductuloinsular complexes (nesidioblastosis), islet dysplasia (referring to normal-sized or slightly enlarged islets <0.5 mm that contain neuroendocrine cells showing loss of the normal spatial and quantitative arrangement of the normal [alpha], [beta], [delta], and PP cell types), pancreatic micro-adenomatosis (when islet dysplasia is between 0.5-5 mm, it is termed microadenoma-, multiple microadenomas are termed microadenomatosis), and peliosis of the nontumorous islets (17) (Figure 2, A and B).