Multiple endocrine neoplasia type 1

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An inherited neoplasia syndrome characterised by: parathyroid hyperplasia (95%), pituitary adenoma (10%), pancreatic islet hyperplasia, adenoma or carcinoma, and/or adrenal cortical hyperplasia, adenoma and carcinoid tumours.

Molecular pathology
Mutation of MEN1 on chromosome 11.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Multiple endocrine neoplasia type 1 (MEN-1)

An inherited condition marked by multiple malignancies of the pituitary gland, parathyroid gland, and islet cells of the pancreas. About half of MEN-1 patients with pancreatic islet cell tumors will have gastrinomas, gastrin-producing tumors that lead to ulcer disease.
Mentioned in: Gastrinoma
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Around 80% of gastrinomas are sporadic in nature, while approximately 20-30% have been found in association with multiple endocrine neoplasia, type 1 (MEN-1) [9].
Ward et al., "A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors," Proceedings of the National Academy of Sciences of the United States of America, vol.

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