Multiple endocrine neoplasia type 1

(redirected from Multiple endocrine neoplasia, type 1)

MEN 1

An inherited neoplasia syndrome characterised by: parathyroid hyperplasia (95%), pituitary adenoma (10%), pancreatic islet hyperplasia, adenoma or carcinoma, and/or adrenal cortical hyperplasia, adenoma and carcinoid tumours.

Molecular pathology
Mutation of MEN1 on chromosome 11.

Multiple endocrine neoplasia type 1 (MEN-1)

An inherited condition marked by multiple malignancies of the pituitary gland, parathyroid gland, and islet cells of the pancreas. About half of MEN-1 patients with pancreatic islet cell tumors will have gastrinomas, gastrin-producing tumors that lead to ulcer disease.
Mentioned in: Gastrinoma
References in periodicals archive ?
Around 80% of gastrinomas are sporadic in nature, while approximately 20-30% have been found in association with multiple endocrine neoplasia, type 1 (MEN-1) [9].
Ward et al., "A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors," Proceedings of the National Academy of Sciences of the United States of America, vol.

Medical browser ?
Full browser ?