multidrug resistance

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1. opposition, or counteracting force, as opposition of a conductor to passage of electricity or other energy or substance.
2. the natural ability of a normal organism to remain unaffected by noxious agents in its environment; see also immunity.
3. in psychology or psychiatry, conscious or unconscious defenses against change, preventing repressed material from coming into awareness; they can take such forms as forgetfulness, evasions, embarrassment, mental blocks, denial, anger, superficial talk, intellectualization, or intensification of symptoms. It occurs because the blocked association or understanding would be too threatening to face at this point in the therapy; identification of what point the resistance comes at can be an important indicator of the patient's unconscious patterns.
airway resistance the opposition of the tissues of the air passages to air flow: the mouth-to-alveoli pressure difference divided by the rate of air flow. Symbol RA or RAW.
androgen resistance resistance of target organs to the action of androgens, resulting in any of a spectrum of defects from a normal male phenotype in which men have normal genitalia but infertility to complete androgen resistance in which the individual has a female phenotype. Complete androgen resistance is an extreme form of male pseudohermaphroditism in which the individual is phenotypically female but is of XY chromosomal sex; there may be rudimentary uterus and tubes, but the gonads are typically testes, which may be abdominal or inguinal in position. Called also testicular feminization and testicular feminization syndrome. Incomplete androgen resistance is any of various forms less than the complete type, manifested by a male phenotype with various degrees of ambiguous genitalia such as hypospadias and a small vaginal pouch, a hooded phallus, or a bifid scrotum that may or may not contain gonads.
drug resistance the ability of a microorganism to withstand the effects of a drug that are lethal to most members of its species.
insulin resistance see insulin resistance.
multidrug resistance (multiple drug resistance) a phenomenon seen in some malignant cell lines: cells that have developed natural resistance to a single cytotoxic compound are also resistant to structurally unrelated chemotherapy agents. Called also cross-resistance.
peripheral resistance resistance to the passage of blood through the small blood vessels, especially the arterioles.
pulmonary vascular resistance the vascular resistance of the pulmonary circulation; the difference between the mean pulmonary arterial pressure and the left atrial filling pressure divided by the cardiac output. Called also total pulmonary vascular resistance.
total peripheral resistance the vascular resistance of the systemic circulation: the difference between the mean arterial pressure and central venous pressure divided by the cardiac output.
total pulmonary resistance (total pulmonary vascular resistance) pulmonary vascular resistance.
vascular resistance the opposition to blood flow in a vascular bed; the pressure drop across the bed divided by the blood flow, conventionally expressed in peripheral resistance units. Symbol R or R.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

mul·ti·drug re·sis·tance (MDR),

the insensitivity of various tumors to a variety of chemically related anticancer drugs; mediated by a process of inactivating the drug or removing it from the target tumor cells.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
London, United Kingdom, November 25, 2018 --( As the worldwide danger of antimicrobial resistance remains a threat, the scientific community continues to inspire the global commitment to tackling multidrug-resistance.
In this study, we have examined the proportions of and trends in Multidrug-Resistance (MDR) among Acinetobacter spp.
The incidence of antibiotic resistance, (ABR), and the emergence of multidrug-resistance bacteria are on the increase they are considered a major public health issue currently.
Cole, "Mammalian multidrug-resistance proteins (MRPs)," Essays in Biochemistry, vol.
Willingham, "Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues," Proceedings of the National Academy of Sciences of United States of America, vol.
The multidrug-resistance phenotype was explained by the presence of an 89,000-bp IncFII plasmid designated p183660 (GenBank accession no.
Enhancing macrocydic diterpenes as multidrug-resistance reversers: structure-activity studies on jolkinol D derivatives.
Given the multidrug-resistance crisis, we should feel obligated to try one of the proposed strategies for delayed antibiotic prescription if patients do not need one right away.
Elbling et al., "Expression and functional activity of the ABC-transporter proteins P-glycoprotein and multidrug-resistance protein 1 in human brain tumor cells and astrocytes," Journal of Neuro-Oncology, vol.
Expression of a multidrug-resistance gene in human tumors and tissues.
The data reinforce the general concern about the spread of multidrug-resistance and virulence genes between avian and human E.
However, past studies didn't investigate the chemicals' effects on the cellular bilge pumps, which scientists call efflux pumps, multidrug-resistance transporters, and various other names.

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