multidrug resistance

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1. opposition, or counteracting force, as opposition of a conductor to passage of electricity or other energy or substance.
2. the natural ability of a normal organism to remain unaffected by noxious agents in its environment; see also immunity.
3. in psychology or psychiatry, conscious or unconscious defenses against change, preventing repressed material from coming into awareness; they can take such forms as forgetfulness, evasions, embarrassment, mental blocks, denial, anger, superficial talk, intellectualization, or intensification of symptoms. It occurs because the blocked association or understanding would be too threatening to face at this point in the therapy; identification of what point the resistance comes at can be an important indicator of the patient's unconscious patterns.
airway resistance the opposition of the tissues of the air passages to air flow: the mouth-to-alveoli pressure difference divided by the rate of air flow. Symbol RA or RAW.
androgen resistance resistance of target organs to the action of androgens, resulting in any of a spectrum of defects from a normal male phenotype in which men have normal genitalia but infertility to complete androgen resistance in which the individual has a female phenotype. Complete androgen resistance is an extreme form of male pseudohermaphroditism in which the individual is phenotypically female but is of XY chromosomal sex; there may be rudimentary uterus and tubes, but the gonads are typically testes, which may be abdominal or inguinal in position. Called also testicular feminization and testicular feminization syndrome. Incomplete androgen resistance is any of various forms less than the complete type, manifested by a male phenotype with various degrees of ambiguous genitalia such as hypospadias and a small vaginal pouch, a hooded phallus, or a bifid scrotum that may or may not contain gonads.
drug resistance the ability of a microorganism to withstand the effects of a drug that are lethal to most members of its species.
insulin resistance see insulin resistance.
multidrug resistance (multiple drug resistance) a phenomenon seen in some malignant cell lines: cells that have developed natural resistance to a single cytotoxic compound are also resistant to structurally unrelated chemotherapy agents. Called also cross-resistance.
peripheral resistance resistance to the passage of blood through the small blood vessels, especially the arterioles.
pulmonary vascular resistance the vascular resistance of the pulmonary circulation; the difference between the mean pulmonary arterial pressure and the left atrial filling pressure divided by the cardiac output. Called also total pulmonary vascular resistance.
total peripheral resistance the vascular resistance of the systemic circulation: the difference between the mean arterial pressure and central venous pressure divided by the cardiac output.
total pulmonary resistance (total pulmonary vascular resistance) pulmonary vascular resistance.
vascular resistance the opposition to blood flow in a vascular bed; the pressure drop across the bed divided by the blood flow, conventionally expressed in peripheral resistance units. Symbol R or R.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

mul·ti·drug re·sis·tance (MDR),

the insensitivity of various tumors to a variety of chemically related anticancer drugs; mediated by a process of inactivating the drug or removing it from the target tumor cells.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
Strengthening OpGen's entry into the United States market, the companies have entered into an agreement to commercialize a new solution for the detection of multidrug resistant bacterial pathogens based on Qiagen's EZ1 Advanced XL automated nucleic acid purification instrumentation and kits for the United States.
In our study, most of the Acinetobacter isolates were obtained from respiratory samples and also mechanical ventilation was found to be a significant risk factor for multidrug resistant samples.
M2 EQUITYBITES-March 7, 2018-Theratechnologies reports US FDA approval for breakthrough multidrug resistant HIV-1 therapy Trogarzo
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Senior author of the report Peter Cegielski, who also works with the CDC's Global TB Branch, told NPR that survival rates for multidrug resistant (MDR) TB and extensively drug resistant (XDR) TB are far worse than plain TB.
In vitro activity of tigecycline in combination with various antimicrobials against multidrug resistant Acinetobacter baumannii.
The most critical group of all includes multidrug resistant bacteria that pose a particular threat in hospitals and nursing homes and among patients whose care requires devices such as ventilators and blood catheters.
In a small study of about 100 North Carolina hog workers and 80 members of their households, researchers found that 44 percent of workers and 39 percent of household members had Staphylococcus aureus strains in their noses, with half of the worker strains and about one-third of the household strains being multidrug resistant. The study, published in November in PLOS One, also found that 6 percent of the workers and 11 percent of children who lived with them reported recent skin and soft tissue infections.
New World Health Organization (WHO) recommendations aim to speed up detection and improve treatment outcomes for multidrug resistant tuberculosis (MDR-TB) through use of a novel rapid diagnostic test and a shorter, cheaper treatment regimen.
The use of short regimens for treatment of multidrug resistant tuberculosis [cited 2015 May 20].
has entered an alliance with Cantab Anti-infectives to develop improved antibiotics to treat multidrug resistant Gram-negative bacterial infections.

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