multidrug resistance

(redirected from Multi-drug resistance)


1. opposition, or counteracting force, as opposition of a conductor to passage of electricity or other energy or substance.
2. the natural ability of a normal organism to remain unaffected by noxious agents in its environment; see also immunity.
3. in psychology or psychiatry, conscious or unconscious defenses against change, preventing repressed material from coming into awareness; they can take such forms as forgetfulness, evasions, embarrassment, mental blocks, denial, anger, superficial talk, intellectualization, or intensification of symptoms. It occurs because the blocked association or understanding would be too threatening to face at this point in the therapy; identification of what point the resistance comes at can be an important indicator of the patient's unconscious patterns.
airway resistance the opposition of the tissues of the air passages to air flow: the mouth-to-alveoli pressure difference divided by the rate of air flow. Symbol RA or RAW.
androgen resistance resistance of target organs to the action of androgens, resulting in any of a spectrum of defects from a normal male phenotype in which men have normal genitalia but infertility to complete androgen resistance in which the individual has a female phenotype. Complete androgen resistance is an extreme form of male pseudohermaphroditism in which the individual is phenotypically female but is of XY chromosomal sex; there may be rudimentary uterus and tubes, but the gonads are typically testes, which may be abdominal or inguinal in position. Called also testicular feminization and testicular feminization syndrome. Incomplete androgen resistance is any of various forms less than the complete type, manifested by a male phenotype with various degrees of ambiguous genitalia such as hypospadias and a small vaginal pouch, a hooded phallus, or a bifid scrotum that may or may not contain gonads.
drug resistance the ability of a microorganism to withstand the effects of a drug that are lethal to most members of its species.
insulin resistance see insulin resistance.
multidrug resistance (multiple drug resistance) a phenomenon seen in some malignant cell lines: cells that have developed natural resistance to a single cytotoxic compound are also resistant to structurally unrelated chemotherapy agents. Called also cross-resistance.
peripheral resistance resistance to the passage of blood through the small blood vessels, especially the arterioles.
pulmonary vascular resistance the vascular resistance of the pulmonary circulation; the difference between the mean pulmonary arterial pressure and the left atrial filling pressure divided by the cardiac output. Called also total pulmonary vascular resistance.
total peripheral resistance the vascular resistance of the systemic circulation: the difference between the mean arterial pressure and central venous pressure divided by the cardiac output.
total pulmonary resistance (total pulmonary vascular resistance) pulmonary vascular resistance.
vascular resistance the opposition to blood flow in a vascular bed; the pressure drop across the bed divided by the blood flow, conventionally expressed in peripheral resistance units. Symbol R or R.

mul·ti·drug re·sis·tance (MDR),

the insensitivity of various tumors to a variety of chemically related anticancer drugs; mediated by a process of inactivating the drug or removing it from the target tumor cells.
References in periodicals archive ?
In late May, FDA granted Breakthrough Therapy Designation for the development of GS-6207 for the treatment of HIV-1 infection in heavily treatment experienced patients with multi-drug resistance.
Table 2: Base line characteristics of the patients enrolled in the study and the development of multi-drug resistance.
KOHAT -- The eight tuberculosis diagnostic centres in Kohat received 340 cases, including nine untreatable multi-drug resistance (MDR) cases, in the first four months of 2019, with most of the patients coming from religious seminaries.
In a statement, Demuris said: "New antibiotics are urgently needed to combat the rise of multi-drug resistance (MDR), and the most pressing are treatments for MDRGram-negative pathogens.
He said more than 30 hospitals had been upgraded to take care of multi-drug resistance TB cases and 13 labs equipped with state of the art facilities are being established in various part of the country.
He detailed that more than 30 hospitals have been upgraded to take care of multi-drug resistance TB cases and 13 labs equipped with state of the art facilities are being established in various part of the country.
I am pleased to note that more than 30 hospitals have been upgraded to take care of multi-drug resistance TB cases and 13 labs equipped with state of the art facilities are being established in various part of the country.
Now we have terminologies like multi-drug resistance (MDR), extensive drug resistance (XDR)12 and Super Bugs, each highlighting the magnitude of problem.
The participants will keep delivering lectures for three days in various sessions of the conference on topics such as DNA vaccine against tuberculosis, multi-drug resistance, enhance production of anti-fungal compound through genome intervention, exploring genes network of lungs cancer's NGD data using advanced bio-informatics techniques and other relevant topic akin to the conference theme.
Multi-drug resistance tuberculosis (MDR-TB) is a disease that is caused by strain of mycobacterium tuberculosis (M.TB) that is resistant to both isoniazid and rifampicin; two of the most powerful anti-TB drugs.
This Antibiotic-Resistant Gene (ARG), originally found in Indian clinical settings, conditionally provides multi-drug resistance (MDR) in microorganisms, revealed the research team from UK's Newcastle University.
Damien Foundation's general director, Brussels, Belgium, Mr Alex Jaucot, said the foundation decided to put up the investment i because of the deadly nature of the multi-drug resistance tuberculosis.

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