anti-mullerian hormone

(redirected from Mullerian inhibiting factor)

mül·le·ri·an in·hib·it·ing sub·stance (MIS),

a 535-amino acid glycoprotein secreted by the Sertoli cells of the testis. It is related to inhibin.
Farlex Partner Medical Dictionary © Farlex 2012


A gene on chromosome 19p13.3 that encodes anti-Müllerian hormone, a member of the transforming growth factor-beta gene family, which mediates male sexual differentiation. AMH causes regression of Müllerian ducts, which would otherwise differentiate into the uterus and fallopian tubes.
Molecular pathology
AMH mutations result in persistent Müllerian duct syndrome.

müllerian inhibiting substance

A 59 kD glycosylated preproprotein of the TGF-beta family encoded by AMH on chromosome 19p13.3 and produced by Sertoli cells in the prepubertal testes, which promotes müllerian duct involution during normal male sexual differentiation. The lack of MIS results in persistent müllerian duct syndrome.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
[1] The syndrome is caused either by an insufficient amount of Mullerian inhibiting factor (MIF) or due to insensitivity of the target organ to MIF.
The female Mullerian ducts regress concurrently due to the presence of a hormone called Mullerian inhibiting factor. At about 10 weeks, the embryo arrives at the fifth fork, where the process of masculinizing external genitalia begins.
The functioning testes produce Mullerian inhibiting factor, however, which prevents a uterus and female tubes from forming.