Muir-Torre syndrome


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Tor·re syn·drome

(tor'ē),
multiple sebaceous gland adenomas associated with multiple visceral malignancies, often colorectal carcinoma.
Synonym(s): Muir-Torre syndrome

Tor·re syn·drome

(tor'ē),
multiple sebaceous gland adenomas associated with multiple visceral malignancies, often colorectal carcinoma.
Synonym(s): Muir-Torre syndrome

Muir-Torre syndrome

(myo͝or′tôr′ā, -ē)
n.
An autosomal dominant condition characterized by multiple tumors of the sebaceous glands and one or more visceral malignancies, especially of the gastrointestinal tract.

Muir-Torre syndrome

A rare autosomal-dominant condition, formally defined as > 1 sebaceous skin tumour (e.g., sebaceous proliferation, sebaceoma), and > 1 internal (visceral) malignancy (e.g., colorectal, bladder, renal pelvis, breast, endometrial, haematologic, lung).
 
The skin tumours that develop in MTS are atypical and low-grade, not metastatic, and are cured by excision.

Muir-Torre syndrome

A condition characterized by multiple internal CAs–colon, bladder, lung, sebaceous proliferation, and keratoacanthomas

Muir,

Edward G., English surgeon, 1906-1973.
Muir-Torre syndrome - Synonym(s): Torre syndrome

Torre,

Douglas P., U.S. dermatologist, 1919–.
Muir-Torre syndrome - Synonym(s): Torre syndrome
Torre syndrome - multiple sebaceous gland neoplasms associated with multiple visceral malignancies. Synonym(s): Muir-Torre syndrome
References in periodicals archive ?
Extraocular sebaceous carcinomas are those that occur away from the eye; these tumors are more likely to be associated with MTS (see below discussion of sebaceous neoplasms and Muir-Torre syndrome), particularly when located away from the head and neck.
Muir-Torre syndrome is a variant of hereditary nonpolyposis colorectal cancer syndrome (also referred to as Lynch syndrome).
Brown, "Muir-Torre syndrome," Archives of Pathology & Laboratory Medicine, vol.
Vermi et al., "The Muir-Torre syndrome: a typical case of misdiagnosis and consequent worsened prognosis," International Journal of Colorectal Disease, vol.
An awareness of the potential for associated malignancies as a component of Muir-Torre Syndrome is necessary to appropriately workup and manage such patients.
Muir-Torre Syndrome (MTS) is a rare autosomal-dominant disorder, described independently by Muir, Yates Bell, Barlow (1) and Torre (2) that is characterized by the predisposition to both sebaceous neoplasms and internal malignancies.
The Muir-Torre syndrome in kindreds with hereditary nonpolyposis colorectal cancer (Lynch syndrome): A classic obligation in preventive medicine.
Fifty-two percent of MMR mutation carriers did not meet clinical diagnostic criteria for Lynch syndrome, and 11 o (f 25 (44%) did not meet the clinical definition) of Muir-Torre syndrome, suggesting potential utility in universal IHC screening of sebaceous neoplasms.
Muir-Torre syndrome is rare, with approximately 200 cases reported.
Molecular Pathology.--HNPCC and Muir-Torre syndrome show defects in mismatch-repair genes.
Muir-Torre syndrome is an autosomal-dominant syndrome defined by the presence of at least one sebaceous gland tumor and the presence of an internal malignancy.
Data field modifier points were captured for a clinical history of multiple carcinomas, most specifically, Muir-Torre syndrome.