Detection of Muerto Canyon virus
RNA in peripheral blood mononuclear cells from patients with hantavirus pulmonary syndrome.
Using an enzyme-linked immunoglobulin M (IgM) capture immunosorbent assay (ELISA), elevated hantavirus IgM titers were found for the Muerto Canyon virus
(MCV) (proposed to be renamed Sin Nombre virus).
A serum sample collected 11 days after onset of illness contained immunoglobulin G (IgG) antibody when tested with Muerto Canyon virus
(MCV) antigen, but no antibody could be detected by immunoglobulin M (IgM) capture enzyme-linked immunosorbent assay (ELISA); moreover, the IgG titer was unchanged when a serum sample obtained 6 weeks later was tested at CDC.
Muerto Canyon virus has been proposed as the name for this virus, following standard conventions for naming zoonotic viruses after a nearby geographic feature.
The case-fatality rate for persons infected with Muerto Canyon virus has been substantially (more than 10 times) higher than that for persons infected with other hantaviruses (8).