cicatricial pemphigoid

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cic·a·tri·cial pem·phi·goid

(sik'ă-trish'ăl pem'fi-goyd)
A chronic disease that produces adhesions and progressive cicatrization and shrinkage of the conjunctival, oral, and vaginal mucous membranes.

pemphigoid, cicatricial 

A rare, idiopathic, chronic systemic disease, most commonly of the elderly and characterized by recurrent blisters and bullae of the skin and mucous membranes, with subsequent scarring and shrinkage. The disease may affect only the conjunctiva (ocular pemphigoid). In this case, the clinical picture is a conjunctivitis with hyperaemia, mucous discharge and small vesicles, which on bursting result in ulceration, pseudomembranes, conjunctival subepithelial fibrosis and conjunctival shrinkage. The disease may give rise to adhesion between the palpebral and bulbar conjunctiva (symblepharon), ankyloblepharon, xerophthalmia, keratoconjunctivitis sicca, entropion, trichiasis and dry eye with corneal ulcer. There is pain or irritation and blurred vision. Treatment includes corticosteroids, surgery for entropion and trichiasis, and keratoprosthesis if vision is affected. Syn. benign mucous pemphigoid. See pseudomembranous conjunctivitis; Stevens-Johnson syndrome; ocular ferning test.

be·nign mu·cous mem·brane pem·phi·goid

(bĕ-nin myūkŭs membrān pemfi-goyd)
Blistering disease chiefly involving the subepidermal mucous membranes of mouth and eye (ocular pemphigus); usually chronic, benign, and typically bilateral. Scarring can occur and may lead to progressive shrinkage and tightening of the affected mucous membranes and connective tissues.
Synonym(s): cicatricial pemphigoid, ocular cicatricial pemphigoid.
References in periodicals archive ?
Sollecito, "Mucous membrane pemphigoid," Dental Clinics of North America, vol.
Caux et al., "Definitions and outcome measures for mucous membrane pemphigoid: recommendations of an international panel of experts," Journal of the American Academy of Dermatology, vol.
A clinical study of oral mucous membrane pemphigoid. J Int Med Res 2003;31(4):340-344.
She was diagnosed by the biopsy of her corneal lesion and immunofluorescence studies which was consistent with the diagnosis of mucous membrane pemphigoid. In past she was treated with methotrexate and prednisone.
Mucous membrane pemphigoid is generally diagnosed with a combination of clinical and immunopathological findings.
Combined treatment of periodontal disease and benign mucous membrane pemphigoid. Case report with 8 years maintenance.
Mucous membrane pemphigoid (MMP) is a group of immune-mediated chronic blistering conditions.
* Mucous membrane pemphigoid is pathophysiologically similar to BP, but distributes preferentially on mucosal surfaces.
This test is not specific for PV, however, because it can be provoked in other diseases such as paraneoplastic pemphigus, oral lichen planus, mucous membrane pemphigoid, epidermolysis bullosa, linear IgA disease, lupus erythematosus, dermatomyositis, chronic erythema multiforme, or graft versus-host disease (6).
Mucous membrane pemphigoid. Treatment experience at two institutions.
A detailed history and physical examination are usually sufficient to diagnose OLP, although laboratory studies and biopsy may be required to exclude malignancy or distinguish OLP from conditions such as pemphigus vulgaris and mucous membrane pemphigoid. A biopsy is rarely needed, and should only be performed by physicians that have training in a tongue biopsy.
The conjunctiva in acute and chronic mucous membrane pemphigoid. An immunohistochemical analysis.