moxonidine


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moxonidine

Cardiology An antihypertensive of the selective imidazoline receptor agonist family which may be useful in managing CHF. See MOXCON, SIRA.

moxonidine

A drug that causes arteries to relax by influencing the action of the sympathetic nervous system. It is used to treat high blood pressure (HYPERTENSION). A brand name is Physiotens.
References in periodicals archive ?
Effects of Moxonidine and Low-Calorie Diet: Cardiometabolic Benefits from Combination of Both Therapies.
Tan et al., "Centrally acting drug moxonidine decreases reactive oxygen species via inactivation of the phosphoinositide-3 kinase signaling in the rostral ventrolateral medulla in hypertensive rats," Journal of Hypertension, vol.
Moreira, "GABA mechanisms of the nucleus of the solitary tract regulates the cardiovascular and sympathetic effects of moxonidine," Autonomic Neuroscience: Basic and Clinical, vol.
Time course of potassium concentration, therapeutic attempts and blood pressure Nebivolol 5 mg qd + Therapy Previous Nebivolol indapamide therapy 5 mg qd 1.5 mg qd + furosemide 40 mg biw Potassium 3.9 6.4 5.5 (mmol/L) Blood 150/100 140/90 150/85 pressure (mm Hg) Verapamil Nebivolol 240 mg qd + Perindopril Therapy 2.5 mg qd + Moxonidine moxonidine 2 mg qd+ moxonidine 0.6 mg qd 0.4 mg qd + indapamide 0.4 mg qd indapamide 0.625 mg qd 1.5 mg qd Potassium 4.5 4.8 4.8 3.8 (mmol/L) Blood 145/85 160/80 160/80 135/80 pressure (mm Hg)
SOME DRUGS THAT CAN CAUSE OR EXACERBATE HEART FAILURE Condition Drugs Arrhythmia dronedarone, flecainide, disopyramide, sotalol Cancer anthracydines and many other agents Depression citalopram, lithium Diabetes thiazolidinediones, dipeptidyl peptidase-4 inhibitors Fungal infections amphotericin B Hypertension doxazosin, diltiazem, verapamil, moxonidine Malaria chloroquine, hydroxychloroquine Migraines ergotamine, methysergide Pain prescription and nonprescription NSAIDs Parkinson's pergolide, pramipexole, bromocriptine Platelet disorders anagrelide, cilostazol Pulmonary disease bosentan, epoprostenol, albuterol Rheumatologic TNF-a inhibitors diseases
Other notable prescription drugs listed as potentially having a major impact on causing or worsening heart failure include the antihypertensive drugs diltiazem, verapamil, and moxonidine, the tumor necrosis factor inhibitors that are widely used to treat rheumatologic and gastroenterologic diseases, the antipsychotic clozapine, and a long list of anticancer medications, including several anthracyclines and many types of newer biologic agents.
Other notable prescription drugs listed as potentially having a major impact on causing or worsening heart failure include the antihypertensive drugs diltiazem, verapamil, and moxonidine, the tumor necrosis factor-inhibitors that are widely used to treat rheumatologic and gastroenterologic diseases, the antipsychotic clozapine, and a long list of anticancer medications, including several anthracyclines and many types of newer biologic agents.
Determination of moxonidine in human plasma by liquid chromatography-electrospray ionization-mass spectrometry.
Wang et al., "Sympathoinhibitory mechanism of moxonidine: role of the inducible nitric oxide synthase in the rostral ventrolateral medulla," Cardiovascular Research, vol.
His daily treatment was fenofibrate, moxonidine, metformin, and enoxaparin 60 mg.
A [beta]-blocker followed by a long-acting [alpha]-blocker or a centrally acting sympatholytic-like moxonidine is a rational strategy.