moxidectin


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moxidectin

(mok-sē-dek'tin),
An injectable macrocylic lactone antiparasitic used for control of Dirofilaria immitis heartworm and Ancylostoma caninum hookworms in heartworm-negative dogs; effect lasts 6 months; a semisynthetic avermectin class derivative of nemadectin isolated from Streptomyces cyaneogriseus subsp. noncyanogenus; less toxic in Collies then ivermectin; also used in horses as an oral gel and in cattle as topical solution; good especially for encysted small strongyles in horses. Mechanism of action is to enhance glutamate gate chloride channel permeabilty of membranes and increase gamma amino butyric acid at presynaptic membranes in nematode and arthropod nerve cells; leads to parasite paralysis and death. Not effective against flukes or tapeworms.
References in periodicals archive ?
BENZIMIDAZOLE CLASS * Albendazole (Valbazen) * Fenbendazole (Panacur; Safe-Guard) * Oxibendazole (Anthelcide) * Oxfendazole (Synanthic) IMIDAZOTHIAZOLE/TETRAHYDROPYRIMIDINE CLASS * Levamisole (Tramisol; Prohibit) * Morantel tartrate (Rumatel) MACROCYCLIC LACTONE CLASS * Ivermectin (Ivomec) * Eprinomectin (Eprinex) * Doramectin (Dectomax) * Moxidectin (Cydectin) Tips for Collecting Fecal Samples Understanding the value of a fecal is paramount in using dewormers correctly.
(15) The use of other anthelmintics, such as fenbendazole, levamisole, mebendazole, moxidectin, thiabendazole, and melarsomine combined with ivermectin, has also been described for treatment of Serratospiculum, (13) Although Diplotriaena species are likely susceptible to common anthelmintics, similar to Serratospiculum, suitable safe doses have yet to be determined for passerine species, such as the New Holland honeyeater.
The Global Health Investment Fund (GHIF) reported on Tuesday the sale of Medicines Development for Global Health's (MDGH) Priority Review Voucher (PRV) following the US Food & Drug Administration (FDA) approval of moxidectin for river blindness (onchocerciasis), a debilitating disease in low-income countries.
Another anti-infective agent that won't be used by those practicing in the United States, but which promises to alleviate a significant source of suffering in the developing world, is moxidectin. The anthelmintic had previously been approved for veterinary uses, but in June 2018, the FDA approved moxidectin to treat onchocerciasis, also known as river blindness.
Bayer Animal Health, a company that aims to improve the health and well-being of pets and farm animals, has launched its Coraxis (moxidectin) Topical Solution for Dogs, a prescription-only, monthly transdermal product that prevents heartworm disease and treats and controls hookworms, roundworms, and whipworms in dogs, it was reported on Friday.
Field tests demostrating reduced activity of ivermectin and moxidectin against small strongyles in horses on 14 farms in Central Kentucky in 2007-2009.
In Experiment 1, 38 Boer x Spanish x Kiko castrated male goats (27.4 [+ or -] 5.7 kg body weight [BW]) were treated for coccidiosis with amprolium (Corid, Merial, GA, USA; 5 mg/kg BW) and dewormed with albendazole (Valbazen, Zoetis, NJ, USA; 10 mg/kg BW) and moxidectin (Cydectin, Boeringer Ingelheim, Ingelheim, Germany; 0.4 mg/kg BW).
Imidacloprid, Moxidectin, Selamectin, Ivermectin, Doramectin and Fipronil.
Phillippo, "Confirmation of Eprinomectin, Moxidectin, Abamectin, Doramectin, and Ivermectin in Beef Liver by Liquid Chromatography/Positive Ion Atmospheric Pressure Chemical Ionization Mass Spectrometry," Journal ofAOAC International, vol.
Control trial and fecal egg count reduction test determinations of nematocidal efficacies of moxidectin and generic ivermectin in recently weaned, naturally infected calves.