mammary tumor virus of mice

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mam·ma·ry tu·mor vi·rus of mice

one of the mammalian Type B retroviruses, antigenically distinct from the murine leukemia-sarcoma complex, which is associated with adenocarcinomatous tumors of the mammary gland, commonly latent in wild and laboratory mice and causing cancer only in genetically susceptible strains under certain hormonal influences.
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John J., U.S. oncologist, 1904-1961.
Bittner agent - member of the retrovirus subfamily Oncornavirinae. Synonym(s): Bittner factor; Bittner milk factor; mammary tumor virus of mice
Bittner factor - Synonym(s): Bittner agent
Bittner milk factor - Synonym(s): Bittner agent
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The mammary adenocarcinoma in certain strains of mice is caused by mouse mammary tumor virus, (MMTV), which is an RNA retrovirus.
A colony of mouse mammary tumor virus (MMTV)-erbB2/neu transgenic mice [FVB/N-TgN(MMTV-neu202Mul)] was established through breeding pairs purchased from Jackson Laboratory (Bar Harbor, ME).
Rodent models used in these studies include dimethylbenz [a] anthracene (DMBA) and nitrosomethylurea (NMU) challenge in rats and mice, and the mouse mammary tumor virus (MMTV) model.
It has been postulated that the mouse mammary tumor virus (MMTV) is essential for the development of mammary gland tumors.

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