mammary tumor virus of mice

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mam·ma·ry tu·mor vi·rus of mice

one of the mammalian Type B retroviruses, antigenically distinct from the murine leukemia-sarcoma complex, which is associated with adenocarcinomatous tumors of the mammary gland, commonly latent in wild and laboratory mice and causing cancer only in genetically susceptible strains under certain hormonal influences.


John J., U.S. oncologist, 1904-1961.
Bittner agent - member of the retrovirus subfamily Oncornavirinae. Synonym(s): Bittner factor; Bittner milk factor; mammary tumor virus of mice
Bittner factor - Synonym(s): Bittner agent
Bittner milk factor - Synonym(s): Bittner agent
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In the untreated tumor cells, the mouse mammary tumor virus (MMTV) occurred in two morphologically distinct forms: A type and B type.
Rodent models used in these studies include dimethylbenz [a] anthracene (DMBA) and nitrosomethylurea (NMU) challenge in rats and mice, and the mouse mammary tumor virus (MMTV) model.

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