MLNR

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MLNR

A gene on chromosome 2q21-q22 that encodes a G protein-coupled receptor for motilin, a 22-amino-acid peptide hormone expressed throughout the GI tract.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The one I have used most commonly is low-dose erythromycin (sub-antibiotic dosage), which is a motilin receptor agonist.
It is a motilin receptor agonist which can promote motilin secretion and thereby enhance the gastric emptying [7].
Erythromycin could stimulate gastrointestinal motility because it acts as a motilin receptor agonist in the gut and gallbladder stimulating enteric nerves and smooth muscle and triggering a phase of the migrating myoelectric complex [18].
The two different types of motilin receptors may cause the different effects of high and low doses of erythromycin.
In animal and human experiments, erythromycin is believed to act on the motilin receptor. A small dose of an oral or intravenous injection can promote gastric migrating motor complex contraction and improve gastric emptying (2,3).
Erythromycin serves as nonpeptide motilin agonist with high affinity for motilin receptors and mimics the biological effects of motilin on the proximal gastrointestinal tract.
The presence of two different types of motilin receptors may account for the discrepancy in responses to a low or intermediate dose of erythromycin.
In the upper gut, this peptide is the most important factor in controlling the interdigestive migrating motor complex (MMC) [31], and motilin receptor agonists have been proposed for treating gastroparesis or conditions with slow gastric emptying [32].
Lamers, "Motilin receptor expression in smooth muscle, myenteric plexus, and mucosa of human inflamed and noninflamed intestine," Inflammatory Bowel Diseases, vol.
Of all the candidate genes for growth traits on chromosome 1, we herein focused our investigation on the motilin receptor (MLNR, chr 1: 173.4 Mb) because it was located just under the QTL peak adjacent to ABR0287 on chromosome 1, and motilin is a key regulatory hormones for appetite (Garthwaite, 1985; Rosenfeld and Garthwaite, 1987), and thus MLNR is a positional and functional candidate gene.
The rabbit motilin receptor: molecular characterization and pharmacology.
Molecular identification and characterization of the dog motilin receptor. Regul.