TMPRSS13

(redirected from Mosaic serine protease)

TMPRSS13

A gene on chromosome 11q23 that encodes a serine protease of unknown function.
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The processing proteases of HPAI HA known to date are Furin and pro-protein convertases (PCs), (28),(29) and type II membrane proteases, mosaic serine protease large-form (MSPL)/TMPRSS13 found by us.
Furin cleaves only HA with the [R.bar]-X-K/R-R motif in the presence of calcium but not the other motif, whereas type II membrane proteases, mosaic serine protease large form (MSPL) and its splice variant transmembrane protease serine 13 (TMPRSS13) recently found by us, with unique substrate recognition of paired basic residues at the cleavage site, efficiently cleave both type motifs, [K/R.bar]-K/R-K/T-R, even under calcium-free conditions, (30) suggesting that these type II membrane proteases facilitate the replication of a wide range of strains of HPAI virus subtypes.
et al., 2010 HAT: type II membrane protein human airway trypsin-like protease; TMPRSS2: transmembrane protease serine 2; MSPL: mosaic serine protease large form; TMPRSS13: transmembrane protease serine 13; M.W.: molecular weight, KSTI; Kunitz- type soybean trypsin inhibitor; BBSTI: Bowman-Birk soybean trypsin inhibitor; GI: gastrointestinal; GUT: genitourinary tract; HDD: 2,2-hydroxydiartlamide derivatives; BOCL: Benzyloxycarbonyl lysine, ND: not determined.