HSPA9

(redirected from Mortalin)

HSPA9

A gene on chromosome 5q31.1 that encodes a member of the heat shock protein 70 (HSP70) family which localises to the mitochondria as well as the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. HSPA9 plays a role in cell proliferation, stress response and maintenance of mitochondria; it may play a role in controlling cell proliferation and ageing and act as a chaperone.
References in periodicals archive ?
On the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60.
Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin.
Patterns of p53, p73 and mortalin gene expression associated with hemocyte polyploidy in the soft-shell clam, Mya arenaria.
Presence of HSPA 9 in omental preadipocytes may protect them from apoptosis, because HSPA9 also called as mortalin and is known to have antiapoptotic role.
3 The proteins were subsequently identified by mass spectrometry (MALDI MS/MS) as isoforms of mortalin (a Mr 74,000 protein that belongs to the heat shock protein 70 [Hsp70] family of chaperone proteins), with significant differences in regulation and phosphorylation among the isoforms.
Parkin purges damaged organelles from the vital mitochondrial network (Tanaka, 2010) and rescues mitochondrial dysfunction induced by knockdown of mortalin, mutation in whose gene is the most common cause of autosomal recessive PD (Yang et al.
It would help to clearly establish the cell types and cellular events that are associated with regeneration-specific changes in gene expression, as exemplified in recent experiments focusing on two cancer-related genes, survivin and mortalin (discussed below).
2006) also reported sequestration of p53 protein complexed with mortalin (a Hsp70 family member) to the cytoplasm of neoplastic cells in M.
b) Score (c) Striatum 1 Albumin-fragment Q8CG74 89 2 Albumin 1 Q8C7H3 308 3 Mortalin GRP75_MOUSE 213 4 Methylglyoxalase LGUL_MOUSE 74 5 Stathmin STN1_MOUSE 103 6 Stathmin STN1_MOUSE 137 7 Stathmin STN1_MOUSE 106 8 Neuromodulin (Gap-43) P06837 92 9 Neuromodulin (Gap-43) P06837 85 Hippocampus 1 Mortalin GRP75_MOUSE 125 2 CCT (TCP-1) TCPB_MOUSE 242 3 Atp5b ATPB_MOUSE 219 4 Macropain Q8BKU2 125 5 Gamma enolase ENOG_MOUSE 229 6 Gamma enolase ENOG_MOUSE 256 7 Alpha enolase ENOA_MOUSE 216 8 Laminin receptor 1 P14206 148 9 Idh3a Q9D6R2 101 10 Synuclein, alpha 09CXFB 114 No.