monospecific

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monospecific

 [mon″o-spĕ-sif´ik]
having an effect only on a particular kind of cell or tissue, or reacting with a single antigen, as a monospecific antiserum.
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As in immunoblot of murine tissues (Figure 1, A), we observed monospecificity of D3G7H in human glioblastoma samples (Figure 2, F).
Monospecificity of monoclonal antibodies may limit their applications as the reactivity of these antibodies can be affected by a small change in the structure of an epitope including genetic polymorphism, glycolsylation, and denaturation.
This correlation may be caused by the monospecificity as well as the high affinity of the antiserum, which is also reflected by the tolerance to pH changes and different salt concentrations.