monocyte

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Related to Monocytes: Lymphocytes, Basophils, Eosinophils, Neutrophils

monocyte

 [mon´o-sīt]
a mononuclear, phagocytic leukocyte, 13 μm to 25 μm in diameter, having an ovoid or kidney-shaped nucleus and azurophilic cytoplasmic granules. Monocytes are derived from promonocytes in the bone marrow and circulate in the blood for about 24 hours before migrating to the tissues, such as the lung and liver, where they develop into macrophages. adj., adj monocyt´ic.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

mon·o·cyte

(mon'ō-sīt),
A relatively large mononuclear leukocyte (16-22 mcm in diameter) that normally constitutes 3-7% of the leukocytes of the circulating blood and is normally found in lymph nodes, spleen, bone marrow, and loose connective tissue. When treated with the usual dyes, monocytes manifest an abundant pale blue or blue-gray cytoplasm that contains numerous fine, dustlike, red-blue granules; vacuoles are frequently present; the nucleus is usually indented, or slightly folded, and has a stringy chromatin structure that seems more condensed where the delicate strands are in contact. Monocytes that leave the bloodstream and enter the connective tissue spaces are called macrophages.
See also: monocytoid cell, endothelial leukocyte.
[mono- + G. kytos, cell]
Farlex Partner Medical Dictionary © Farlex 2012

monocyte

(mŏn′ə-sīt′)
n.
A large, circulating, phagocytic white blood cell, having a single well-defined nucleus and very fine granulation in the cytoplasm. Monocytes constitute from 3 to 8 percent of the white blood cells in humans.

mon′o·cyt′ic (-sĭt′ĭk), mon′o·cy′toid′ (-sī′toid′) adj.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

monocyte

Hematology A phagocytic WBC that arises in BM from a common progenitor, CFU-GM; 'daughter' monocytes circulate in the blood, forming resident and transient populations in various sites; resident monocytes–histiocytes include Kupffer cells–liver, Langerhans cells–dermis, microglial cells–brain, pleural, peritoneal, alveolar macrophages and osteoclasts; monocytes normally constitute 2%–8% of peripheral WMCs, measure 12-25 µm, have a reniform nucleus with lacy chromatin, an N:C ratio of 4:1 to 2:1, and gray blue cytoplasm containing lysosomal enzymes–eg, acid phos, arginase, cathepsins, collagenases, deoxyribonuclease, lipases, glycosidases, plasminogen activator and others, and surface receptors–eg, FcIgG and C3R; monocytes are less efficient in phagocytosis than PMNs, but have a critical role in antigen processing. See CFU-GM, White blood cell.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

mon·o·cyte

(mon'ō-sīt)
A relatively large mononuclear leukocyte (16-22 mcm in diameter); monocytes normally constitute 3-7% of the leukocytes of the circulating blood; normally found in lymph nodes, spleen, bone marrow, and loose connective tissue. In stained smears, monocytes have abundant pale blue or blue-gray cytoplasm that contains numerous fine red-blue granules and vacuoles; the nucleus is usually indented, or slightly folded.
[mono- + G. kytos, cell]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
Enlarge picture
MONOCYTES: (Orig. mag. ×640)

monocyte

(mon'o-sit?) [ mono- + -cyte],

MO

A mononuclear phagocytic white blood cell derived from myeloid stem cells. Monocytes circulate in the bloodstream for about 24 hr and then move into tissues, at which point they mature into macrophages, which are long lived. Monocytes and macrophages are one of the first lines of defense in the inflammatory process. This network of fixed and mobile phagocytes that engulf foreign antigens and cell debris previously was called the reticuloendothelial system and is now referred to as the mononuclear phagocyte system (MPS).
See: illustration; blood for illus.; macrophagemonocytic (mon-o-sit'ik), adjectiveillustration
Medical Dictionary, © 2009 Farlex and Partners

monocyte

A large white blood cell with a round or kidney-shaped nucleus. There are no granules in the CYTOPLASM. The monocyte migrates to the tissues where it becomes a MACROPHAGE.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

monocyte

or

macrocyte

a type of LEUCOCYTE (white blood cell) of the AGRANULOCYTE group that is produced from stem cells in the bone marrow and is 12–15 μm in diameter. Monocytes remain in the blood for a short time and then migrate to other tissues as MACROPHAGES, moving particularly to those areas invaded by bacteria and other foreign materials where they ingest large particles by PHAGOCYTOSIS. See also HISTOCYTE, LYMPHOCYTE.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

Monocyte

White blood cell that increases during a variety of conditions including severe infections. It removes debris and microorganisms by phagocytosis.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.

mon·o·cyte

(mon'ō-sīt)
A relatively large mononuclear leukocyte that normally constitutes 3-7% of the leukocytes in circulating blood.
[mono- + G. kytos, cell]
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Monocytes are members of the mononuclear phagocyte system that comprises monocytes, dendritic cells, and macrophages.
Galli et al., "Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors," Cancer Cell, vol.
The present study provided two novel insights into the effects of advanced glycation end products on bone marrow monocytes, the precursors of the macrophages.
Yamashita, "Phagocytosis by human monocytes is required for the secretion of presepsin," Journal of Infection and Chemotherapy, vol.
In order to evaluate the ability of diabetic monocytes to switch from proinflammatory towards anti-inflammatory phenotype, we measured the surface expression of CD163.
Recently, two studies have been reported on miRNA profiling in monocytes in relation to BMD in postmenopausal Caucasian women [44, 45].
Patients with another chronic disease (coronary artery disease, hematological diseases, malignancies, severe liver disease, severe kidney failure), a diagnosis of rheumatological diseases or infectious diseases (tuberculosis, malaria, Brucella) that progress with inflammation causing an elevated monocyte count, renal diseases besides type 2 diabetes mellitus that cause proteinuria, a diagnosis of type 1 diabetes mellitus, and active psychiatric disorders were excluded from the study.
Despite the fact that there is an association of early biomarker indicating the initial activation monocyte with ferritin level in major beta-thalassemia patients (22), a selectively relative decreased of circulating monocyte population evidenced in animal model of this study preliminarily suggests a monocyte compartment shift from circulation to tissue as a competent immune cell in iron balancing to respond the iron overloaded tissue injury.
The first model is a restricted model with age, minimum monocytes (low/high based on cut-off point), and maximum RDW (low/ high based on cut-off point), whereas the second model is a full model that also included the other significant parameters, such as APACHE II score, hemoglobin, focus of infection, intra-abdominal infection, and blood transfusion.
These samples had CD14+ monocytes isolated from peripheral blood, DNA extracted, and stored and DNA methylation evaluated by Illumina 450K array as previously described (Liu et al.
Originally specified as epithelial cell-associated factor, AREG is nowadays known to be expressed in a variety of activated immune cells [12] including monocytes [13].

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