CCL2

(redirected from Monocyte Chemotactic Protein 1)
Also found in: Acronyms.

CCL2

A gene on chromosome 17q11.2-q21.1 that encodes a protein structurally related to the CXC subfamily of cytokines, which are characterised by two cysteines separated by a single amino acid. CCL2 is chemotactic for monocytes and basophils, but not neutrophils or eosinophils; it binds to chemokine receptors CCR2 and CCR4.

Molecular pathology
Altered expression of CCL2 has been linked to diseases characterised by monocytic infiltrates—e.g., psoriasis, rheumatoid arthritis, atherosclerosis.
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Gene Upstream MCP-1 5'-GAGCCTGACATGCTTTCATCTA-3' NF-[kappa]B 5'-GTTGAGGGGACTTTCCCAGGC-3' [beta]-actin 5'-CATCACGTACCAAACTTCAA-3' Gene Downstream MCP-1 5'-TTTCCATTCACTGCTGAGAC-3' NF-[kappa]B 5'-TCAACTCCCCTGAAAGGGTCCG-3' [beta]-actin 5'-CATCACAGTACCGGATTGC-3' MCP-1: monocyte chemotactic protein 1; NF-[kappa]B: nuclear factor kappa B.
Roles of monocyte chemotactic protein 1 and nuclear factor-[kappa]B in immune response to spinal tuberculosis in a New Zealand white rabbit model
IL: interleukin; IL-1RA: IL-1 receptor antagonist; IL-2RI: L-2 receptor; IFN-[alpha] and IFN-[gamma]: interferon [alpha] and [gamma]; MIG: monokine induced by IFN-[gamma]; TNF[alpha]: tumor necrosis factor [alpha]; EGF: epidermal growth factor; HGFh: epatocyte growth factor; VEGF: vascular endothelial growth factor; MIP-1[alpha] and MIP-1[beta]: macrophage inflammatory protein-1[alpha] and 1[beta]; G-CSF: granulocyte-colony stimulating factor; GM-CSF: granulocyte- macrophage stimulating factor; FGF-basic: basic fibroblast growth factor; MCP-1: eotaxin, monocyte chemotactic protein 1; IP-10: inducible protein 10.
Blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in patients with symptoms suggesting reactive hypoglycemia
who observed that LDL(-) promotes monocyte chemotactic protein 1 (MCP1) and interleukin 8 (IL8) release in human umbilical vein endothelial cells (HUVEC) [7].
Electronegative LDL: a circulating modified LDL with a role in inflammation
Previous studies of PlGF showed that it "stimulates vascular smooth muscle cell growth, recruits macrophages into atherosclerotic lesions, upregulates production of tumor necrosis factor--ct and monocyte chemotactic protein 1 by macrophages, and stimulates pathologic angiogenesis," they noted.
Marker may predict future cardiac events: placental growth factor

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