CCL2

(redirected from Monocyte Chemoattractant Protein 1)
Also found in: Acronyms.

CCL2

A gene on chromosome 17q11.2-q21.1 that encodes a protein structurally related to the CXC subfamily of cytokines, which are characterised by two cysteines separated by a single amino acid. CCL2 is chemotactic for monocytes and basophils, but not neutrophils or eosinophils; it binds to chemokine receptors CCR2 and CCR4.

Molecular pathology
Altered expression of CCL2 has been linked to diseases characterised by monocytic infiltrates—e.g., psoriasis, rheumatoid arthritis, atherosclerosis.
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References in periodicals archive ?
Tee et al., "Relationships of single nucleotide polymorphisms of monocyte chemoattractant protein 1 and chemokine receptor 2 with susceptibility and clinicopathologic characteristics of neoplasia of uterine cervix in Taiwan women," Reproductive Sciences, vol.
[4] Nonstandard abbreviations: CVD, cardiovascular disease; MCP-1, monocyte chemoattractant protein 1; CRP, C-reactive protein; TF, tissue factor; IMT, intima-media thickness; SBP, systolic blood pressure; DBP, diastolic blood pressure; BMI, body mass index; hsCRP, high-sensitivity CRP; LPS, lipopolysaccharide; TBS, Tris-buffered saline; NPC, nonparametric combination.
Segelmark, "Monocyte chemoattractant protein 1 is a prognostic marker in ANCA-associated small vessel vasculitis," Mediators of Inflammation, vol.
Regulation of monocyte chemoattractant protein 1 by cytokines and oxygen free radicals in rat hepatic fat-storing cells.
For example, local concentrations of the proinflammatory mediators LPS and interferon gamma stimulate the polarization of M1 macrophages that are responsible for the initiation of debris clearance and the production of the proinflammatory cytokines IL-1[beta], IL-6, and TNF-[alpha], and the chemokine monocyte chemoattractant protein 1 (MCP-1) [48].
Rosenfeld et al., "Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions," Proceedings of the National Academy of Sciences of the United States of America, vol.

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