monoclonal antibodies

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monoclonal antibodies

ANTIBODIES (immunoglobulins) produced by hybrid B lymphocyte tumours (myelomas). The type of antibodies produced depend on the selection of the B cell. These can be fused to cultured mouse, or even human, myeloma cells to form immortal tumours (hybridomas)-clones of cells that continue indefinitely to generate large quantities of the particular antibody produced by the B cell. The availability of quantities of almost any desired antibody has major diagnostic, therapeutic and research implications and monoclonal antibody production is one of the most important biotechnological advances of the century. Monoclonal antibodies can be made that will seek out and recognize cancers anywhere in the body, and this offers a number of intriguing possibilities for treatment. They are, however, less specific than had been initially thought, and can bind to molecules other than those intended. A serious accident occurred in a therapeutic trial in March 2206.
References in periodicals archive ?
M2 PHARMA-December 8, 2010-A-CUBE, Wakunaga Pharmaceutical enter into agreement on monoclonal therapeutic antibody(C)2010 M2 COMMUNICATIONS
While this technique has generated monoclonals, there is a limiting factor: The antibody in question has to be against a fairly benign substance so that a person could be vaccinated with it.
difficile Toxin A and Toxin B monoclonal antibodies.
Researchers studying this and other cancers have long sought to use monoclonal antibodies -- biological molecules that bind only to particular target cells -- to attack tumors directly or to shuttle toxins selectively to cancer cells.