monoclonal gammopathy of unknown significance

monoclonal gammopathy of unknown significance (MGUS),

a gammopathy diagnosed by electrophoresis of serum of asymptomatic old people who have no other evidence of plasma cell neoplasia; in 20% of cases it evolves into plasma cell malignancy.

mon·o·clo·nal gam·mop·a·thy of un·known sig·ni·fi·cance

(MGUS) (mon'ō-klōn'ăl gam-mop'ă-thē ŭn-nōn' sig-nif'i-kăns)
A gammopathy diagnosed by electrophoresis of serum of asymptomatic old people who have no other evidence of plasma cell neoplasia; in 20% of cases, it evolves into plasma cell malignancy.
Synonym(s): benign monoclonal gammopathy.
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References in periodicals archive ?
The commonly known disease state of monoclonal gammopathy of unknown significance (MGUS) differs from MGRS in that the latter contains objective evidence of renal involvement, indicating end-organ damage.
So far, the longitudinal personal omics analysis has revealed other important diagnoses that likely would have flown under the radar of conventional Western medicine, including a heart defect in one person that was detected by a simple wearable device, a case of early lymphoma, and a case of MGUS (monoclonal gammopathy of unknown significance), which is a precancerous condition.
He was diagnosed with monoclonal gammopathy of unknown significance. Bone marrow biopsy to rule out myeloma was not done.
Those patients without recognizable organ involvement are considered to exhibit a monoclonal gammopathy of unknown significance (MGUS).
The major plasma cell dyscrasias are (1) multiple myeloma, (2) monoclonal gammopathy of unknown significance, (3) solitary plasmacytoma of bone, (4) extramedullary plasmacytoma, and (5) heavy-chain disorders.
In the absence of any other clinical or laboratory evidence of a hematological dyscrasia, a diagnosis of monoclonal gammopathy of unknown significance (MGUS) was made.

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