Monoclonal B-cell lymphocytosis
and early-stage chronic lymphocytic leukemia: diagnosis, natural history, and risk stratification.
Telomere length in relation to age in normal controls, low-count monoclonal B-cell lymphocytosis (population screening MBL), high-count MBL (clinical MBL) and chronic lymphocytic leukemia (CLL) patients measured in telomere/single copy gene ratio (T/S).
Peripheral blood leukocyte and clonal B-cell telomere length matched for age and adjusted in healthy controls, low-count monoclonal B-cell lymphocytosis (LC MBL), high-count MBL (HC MBL) and Binet A chronic lymphocytic leukemia (CLL) patients.
Characteristics Control Low-count MBL Number of subjects 261 6 Medium age 30 69 Age range (years) 0-88 53-82 Gender Cord blood 19 -- Male 125 5 Female 117 1 Medium number of lymphocytes -- 1.466 Range (/[micro]L) -- 800-2100 % [CD5.sup.+] B-lymphocytes -- 1.68 in total lymphocytes Range (%) -- 0.72-3.43 Characteristics High-count MBL CLL Number of subjects 12 21 Medium age 78 70 Age range (years) 57-97 58-81 Gender Cord blood -- -- Male 9 11 Female 3 10 Medium number of lymphocytes 3.933 41.714 Range (/[micro]L) 2.900-5.900 7.500-147.000 % [CD5.sup.+] B-lymphocytes 34.9 78.02 in total lymphocytes Range (%) 5.97-61.01 58.63-91.09 MBL: Monoclonal B-cell lymphocytosis; CLL: chronic lymphocytic leukemia.
Prevalence of monoclonal B-cell lymphocytosis: A systematic review.
B-cell count and survival: differentiating chronic lymphocytic leukemia from monoclonal B-cell lymphocytosis based on clinical outcome.
Clinical and diagnostic implications of monoclonal B-cell lymphocytosis. Best Practice & Research Clinical Haematology.
Monoclonal B-cell lymphocytosis. Hematology Am Soc Hematol Educ Program.
Unexpected detection of monoclonal B-cell lymphocytosis in a HLA-matched sibling donor on the day of allogeneic stem cell transplantation for a patient with chronic lymphocytic leukaemia: clinical outcome.
Monoclonal B-cell lymphocytosis: a brief review for general clinicians.