monobactam

(redirected from Monobactams)
Also found in: Wikipedia.

mon·o·bac·tam

(mon'ō-bak'tam),
A class of antibiotic that has a monocyclic β-lactam nucleus and is structurally different from other β-lactams; for example, aztreonam.
Farlex Partner Medical Dictionary © Farlex 2012

mon·o·bac·tam

(mon'ō-bak'tam)
Antibiotic that has a monocyclic β-lactam nucleus and is structurally different from other β-lactams.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

mon·o·bac·tam

(mon'ō-bak'tam)
Class of antibiotic with a monocyclic β-lactam nucleus: structurally different from other β-lactams.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
These five isolates were tested against twenty-three available antibiotics from, aminoglycosides, tetracyclines, quinolones, [beta]-lactams, monobactams, sulphonamides, macrolides, cephalosporins, phosphonic acid and polypeptide classes of antimicrobials, showed increased resistance.
Carbapenemases represent the most versatile family of [beta]-lactamases that hydrolyze not only carbapenem but other beta-lactams as well, with the sporadic exception of monobactams. The majority of them resist inhibition by all commercially viable beta-lactamase inhibitor (Maltezou, 2009).
Carbapenemases are plasmid-encoded and has reduced the activity of all penicillins, monobactams, cephalosporins and carbapenems.
The [beta]-lactam drugs include Aminopenicillins, Cephalosporins, Carbapenems, and Monobactams. There are different enzymes produced correspondingly against these antibiotics such as penicillinase, cephalosporinases, and carbapenemases22.
However, in AAH, use of monobactams decreased significantly (coefficient -0.2382, p<0.01 [Appendix Table 4]).
* Sterile and high potency APIs, steroids, generics, monobactams, boronic acids and controlled substances
Extended-spectrum beta-lactamases producing organisms break the beta-lactam ring, which leads to resistance to antimicrobials, such as cephalosporins and monobactams. (4) In addition, extensive use of these drugs leads to mutations of ESBL genes and the emergence of ESBL infection.
They confer variable range of resistance to all beta-lactam antibiotics except the monobactams such as aztreonam.
One of these drugs is typically a Beta-lactam antibiotic, a member of a family of antibiotics that includes penicillin derivatives, cephalosporins, monobactams and carbapenems.
To the Editor: Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) produce enzymes that confer resistance to penicillins, cephalosporins and monobactams. [1] ESBL-PE represent a global concern in humans, in animals and in the environment and have therefore been recognised as pathogens of critical priority.