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an induration or hardening, especially of a part from inflammation, or in disease of the interstitial substance. The term is used chiefly for such a hardening of the nervous system due to hyperplasia of the connective tissue or for hardening of the blood vessels. Called also induration. adj., adj sclerot´ic.
amyotrophic lateral sclerosis see amyotrophic lateral sclerosis.
arteriolar sclerosis arteriolosclerosis.
disseminated sclerosis multiple sclerosis.
familial centrolobar sclerosis a progressive familial form of leukoencephalopathy marked by nystagmus, ataxia, tremor, parkinsonian facies, dysarthria, and mental deterioration.
focal glomerular sclerosis focal segmental glomerulosclerosis.
glomerular sclerosis glomerulosclerosis.
hippocampal sclerosis loss of neurons in the region of the hippocampus, with gliosis; sometimes seen in epilepsy.
lateral sclerosis a form seated in the lateral columns of the spinal cord. It may be primary, with spastic paraplegia, rigidity of the limbs, and increase of the tendon reflexes but no sensory disturbances, or secondary to myelitis, with paraplegia and sensory disturbance.
medial calcific sclerosis (Mönckeberg's sclerosis) Mönckeberg's arteriosclerosis.
multiple sclerosis see multiple sclerosis.
systemic sclerosis systemic scleroderma.
tuberous sclerosis a congenital heredofamilial disease, transmitted as an autosomal dominant trait, characterized principally by the presence of hamartomas of the brain (tubers), retina (phakomas), and viscera, mental retardation, seizures, and adenoma sebaceum, and often associated with other skin lesions.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
medial calcific sclerosisA type of dystrophic calcification in which calcium is deposited in the tunica media of arteries.
Medial cystic sclerosis is usually asymptomatic, but may be associated with atherosclerosis, hypertension, diabetes and chronic kidney disease. Areas affected are “pulseless” due to the calcified encasement; areas beyond the sclerosis have a “bounding” pulse.
Affected medium-sized arteries in the upper and lower limbs have linear calcifications, resulting in a so-called pipestem appearance.
Uncertain; an array of calcium-regulating proteins have been implicated, including osteopontin, osteoprotegerin, matrix GLA protein, fetuin-A, receptor activator of NF-kappa-B, receptor activator of NF-kappa-B ligand and TNF-related apoptosis-inducing ligand.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Monckeberg's sclerosisAn age-related degenerative disorder of the muscle coat of medium-sized arteries with severe hardening from CALCIFICATION. The condition causes some rise in systolic blood pressure but is otherwise unimportant. (Johann George Monckeberg, 1877–1925, German physician).
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005