Mönckeberg's arteriosclerosis

(redirected from Monckeberg's arteriosclerosis)
Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to Monckeberg's arteriosclerosis: medial sclerosis, pipestem arteries, medial calcification

arteriosclerosis

 [ahr-te″re-o-sklĕ-ro´sis]
any of a group of diseases characterized by thickening and loss of elasticity of the arterial walls; popularly called “hardening of the arteries.” Symptoms depend on the organ system involved. adj., adj arteriosclerot´ic.ƒ

There are three main forms of arteriosclerosis: (1) atherosclerosis, the most common type, in which plaques of fatty deposits form in the inner layer (tunica intima) of the arteries; (2) Mönckeberg's arteriosclerosis, called also medial calcific sclerosis because of involvement of the middle layer (tunica media) of the arteries, where there is destruction of muscle and elastic fibers and formation of calcium deposits; and (3) arteriolar sclerosis or arteriolosclerosis, which is marked by thickening of the walls of arterioles. All three forms may be present in the same patient, but in different blood vessels. When reference is made to hardening of the arteries, this usually refers to atherosclerosis; the terms arteriosclerosis and atherosclerosis are often used interchangeably.

It is the responsibility of the health care provider to help individuals modify or eliminate from their lives risk factors for the development of arteriosclerosis. These include cigarette smoking, obesity, elevated cholesterol levels, and sedentary life style.
Mönckeberg's arteriosclerosis see arteriosclerosis.
arteriosclerosis obli´terans arteriosclerosis in which proliferation of the intima has caused complete obliteration of the lumen of the artery. Cf. endarteritis obliterans.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

medial calcific sclerosis

A type of dystrophic calcification in which calcium is deposited in the tunica media of arteries.

Clinical findings
Medial cystic sclerosis is usually asymptomatic, but may be associated with atherosclerosis, hypertension, diabetes and chronic kidney disease. Areas affected are “pulseless” due to the calcified encasement; areas beyond the sclerosis have a “bounding” pulse.

Imaging
Affected medium-sized arteries in the upper and lower limbs have linear calcifications, resulting in a so-called pipestem appearance.
 
Pathogenesis
Uncertain; an array of calcium-regulating proteins have been implicated, including osteopontin, osteoprotegerin, matrix GLA protein, fetuin-A, receptor activator of NF-kappa-B, receptor activator of NF-kappa-B ligand and TNF-related apoptosis-inducing ligand.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Full browser ?