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Nephrology The excretion of excessive (> 5 mg/dL) protein in the urine; normally, about 150 mg/day of protein is lost in the urine,13 is albumin,13 is Tamm-Horsfall glycoprotein; the rest is divided among actively secreted proteins–eg, retinol binding proteins, β2-microglobulin, Ig light chains and lysozyme; in absence of disease, large proteins are retained due to their size, while the smaller proteins are actively resorbed; proteinuria is most often caused by kidney disease, due to glomerular defects, and defective renal tubular resorption, and most often detected by screening with reagent strip–dipstick. See Functional proteinuria, Overflow proteinuria.
Proteinuria, severity
Severe ≥ 1.0 g/dL, due to glomerulonephritis, nephrotic syndrome, lupus nephritis, amyloidosis
Moderate ≥ 0.2 g/dL, ≤ 1.0 g/dL, due to CHF, drugs, acute infections, myeloma, chemical toxins
Mild 0.05-0.2 g/dL, due to polycystic kidneys, pyelonephritis, renal tubular defects
Proteinuria, patterns
Glomerular pattern Due to a loss of fixed negative charge on the glomerular capillary wall, allowing albumin and other large (≥ 68 kD) molecules to leak into Bowman's space–eg, in glomerulonephritis and nephrotic syndrome Lab ↓ albumin, antithrombin, transferrin, prealbumin, α1-acid glycoprotein, α1-antitrypsin
Hemodynamic pattern Due to rheostatic changes in the body, causing a loss of 20 to 68 kD molecules, seen in transient proteinuria, CHF, fever, seizures, excess exercise.
Overflow pattern Due to tissue/cell destruction that overwhelms renal capacity to excrete certain proteins–eg, Bence-Jones proteinuria and myoglobinuria
Tubular pattern Due to renal tubular dysfunction with loss of normally filtered low molecular weight (≤ 40 kD) molecules Lab ↓ β2-microglobulin and lysozyme–eg, Fanconi syndrome, Wilson's disease, interstitial nephritis, antibiotic-induced injury and heavy metal intoxication  
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

Patient discussion about Moderate

Q. what does moderate drinking mean? I am addicted to drinks… oops! Not water but alcohol. My well-wishers advised and requested me to drink moderate. Is it so? If I have to hate my habit then I want to know what does moderate drinking mean.

A. To me, you know that you don't drink "moderately" if you are questioning it. And apparently those around you are noticing. The helpful thing is that you know it. Most people who drink will deny it. Maybe you should visit a local AA meeting and get a feel for what you are doing. There is plenty support there. It would be a good thing to nip it in the bud at this early point.

Q. Imedix site has helped me to learn about the symptoms of autism. Thanks for the moderator and the members. Imedix site has helped me to learn about the symptoms of autism. Thanks for the moderator and the members. Now kindly add to my knowledge by letting me know whether there are any indications that require IMMEDIATE evaluation for autism?

A. Thank you Zakary. Though there are many symptoms of autism, a child should definitely be evaluated for autism immediately, if he or she has: No babbling by 12 months, No gesturing (pointing, aving bye-bye, etc.) by 12 months, No single words by 16 months. No two-word (not just echolalic) phrases by 24 months, any loss of any language or social skills at any age.

Q. what are the requirements of getting medicinal marijuana? i'd like to know the requirements of getting prescribed medicinal marijuana. i have heard alot about health benefits of moderate use of marijuana or should i refer to it as cannabis.

A. marijuana has been proven to help in these diseases,but the problem is getting a drs order for it.IT is easyer to get it under the table than legally.

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References in periodicals archive ?
Wind: Light to moderate Southeasterly becoming Northeasterly winds, freshening at times day time causing some blowing dust, with a speed of 20 30, reaching 40 km/hr.
Respondents when interacted with stranger of opposite gender, they used positive politeness with high frequency (N=82, 42.5%), the use of bald off record and bald on record politeness was found moderate while the use of negative politeness strategy was low among all (N=25, 13.0%).
Winds over the rest of the country will be light to moderate moving southeast to south while coastal waters will be slight to moderate.
Her net ratings fell from "good" to "moderate" among class D or the "masa" (down by 7 points from +33 to +26) while it stayed at "good" among class E (down by 2 points from +48 to +46) and "neutral" among class ABC (down by 2 points from +2 to net zero).
The net satisfaction rating of the House rose by one grade from moderate to good, up by 11 points from +25 in June 2018 to +36 in September 2018.
The well-established downsides of excessive drinking -- 37% of Americans say drinking has been a cause of trouble in their families -- make authorities cautious about positive recommendations on moderate drinking.
Light to moderate winds in general, freshening at times.
Moderate to heavy rains lashed the Wilayat of Wadi Bani Khalid, including the villages of Muqul, Badha, Muzaure, Saih Al Rafi, Shrajidil, Al Quhum, accompanied by moderate to strong winds, resulting in the flooding of Wadi Absan and Al Ajma and Wadi Al Sum, in addition to a number of mountain passes.
The studied population had a moderate score in terms of forgiveness.
Of 2,498 participants, 362 were categorized as moderate, nonbinge drinkers before their MI.
"This is the first study to show that moderate drinkers who continue to drink have better outcomes than moderate drinkers who quit.
For the main analyses, the researchers categorized participants' level of depressive symptoms as high, moderate or low; in secondary analyses, they' substituted a continuous measure of depressive symptoms.