haplotype

(redirected from Modal Haplotype)
Also found in: Dictionary, Thesaurus, Encyclopedia.

haplotype

 [hap´lo-tīp]
1. a set of alleles of a group of closely linked genes, such as the HLA complex, which are usually inherited as a unit, an individual inheriting a complete haplotype from each parent.
2. the genetic constitution of an individual at a set of linked genes.

hap·lo·type

(hap'lō-tīp),
1. The genetic constitution of an individual with respect to one member of a pair of allelic genes; individuals are of the same haplotype (but of different genotypes) if alike with respect to one allele of a pair but different with respect to the other allele of a pair.
2. In immunogenetics, that portion of the phenotype determined by a set of closely linked genes inherited from one parent (that is, genes located on one of the pair of chromosomes).
[haplo- + G. typos, impression, model]

haplotype

/hap·lo·type/ (-tīp) the group of alleles of linked genes, e.g., the HLA complex, contributed by either parent; the haploid genetic constitution contributed by either parent.

haplotype

(hăp′lə-tīp′)
n.
A set of alleles of different genes that are closely linked on one chromosome and are usually inherited as a unit.

hap·lo·type

(hap'lō-tīp)
1. The genetic constitution of an individual with respect to one member of a pair of allelic genes; individuals are of the same haplotype (but of different genotypes) if alike with respect to one allele of a pair but different with respect to the other allele of a pair.
2. immunogenetics That portion of the phenotype determined by a set of closely linked genes inherited from one parent (i.e., genes located on one of the pair of chromosomes). The human major histocompatability complex comprises 4 recognized loci (A, B, C, and D) for which there are more than 50 alleles. Similarly, the allotypic markers (antigens) of the immunoglobulin subclasses IgG1, IgG2, IgG3, and IgA2 occur in combinations and are inherited as units almost always unchanged in transmission; the alleles that control these various haploptypes are not linked to those controlling the antigens of the κ type L chains.
[haplo- + G. typos, impression, model]

haplotype

The entire set of allelic variants that may be found at any particular genetic location.

haplotype

see HLA SYSTEM.

Haplotype

A set of alleles (an alternative form of a gene that can occupy a particular place on a chromosome) of a group of closely linked genes which are usually inherited as a unit.

haplotype

the group of alleles of linked genes contributed by either parent; the haploid genetic constitution contributed by either parent.
References in periodicals archive ?
Using the new data, Hammer and his team were able to pinpoint the geographic distribution of a genetically more resolved Cohen Modal Haplotype and tease apart a multiplicity of male lines that founded the priesthood in ancient Hebrew times.
The more fully resolved Cohen Modal haplotype (called the extended Cohen Modal Haplotype) that accounts for almost 30 percent of Cohanim Y chromosomes from both Ashkenazi and non-Ashkenazi Jewish communities, is virtually absent in non-Jews, and likely traces to a common male ancestor that lived some 3,200 years ago in the Near East.
Additional Y chromosome lineages that are distinct from that defined by the extended Cohen Modal Haplotype, but also shared among Cohanim from different Jewish communities, reveal that several unrelated male lines established the priesthood.