MAP3K13

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MAP3K13

An oncogene on chromosome 3q27 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K13 activates the JUN N-terminal pathway by activating the MAP kinase kinase MAP2K7. It acts synergistically with PRDX3 to regulate kinase-dependent NF-kappaB activation in the cytosol, which involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappaB.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Meanwhile, Pence's comments comparing Trump to MLK drew criticism on Twitter.
It is the same playbook they used against MLK, and his response, whether the powers that be want to acknowledge it or not, was to protest against the injustices of the times and disrupt business as usual.
The issue at stake is King's estate that is officially controlled by his three children - sons Dexter and MLK III and daughter Bernice.
MLK Street (Michelson, Alderman, & Popke, 2007) names are symbolic representations honoring Dr.
The hotel will be donating 10 percent of proceeds for hotel rooms booked until December 31, 2011, to the MLK Memorial Foundation.
Dairy producer Milkiland (MLK PW) announced that the lead manager of its IPO on the Warsaw Stock Exchange exercised the greenshoe over-allotment option in full on December 30, 2010 in relation to 749,825 shares at the IPO offer price of PLN 33.78/share.
Wandering MLK is more like being trapped in the body of Falstaff.
Gallegos officially opened the Martin Luther King (MLK) Reading Room at the Islamabad Club in a ceremony today.
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He fought for our rights in the same manner as MLK, using nonviolence and demonstrations to break down stereotypes in a day when being gay was cause for lobotomy, jail, or death.
MLK: Journey of a King by Tonya Bolden Abrams Books for Young Readers/Amulet Books, February 2007 $19.95, ISBN 0-810-95476-1 Ages 10-14