MAP3K12

(redirected from Mixed lineage kinase)

MAP3K12

An oncogene on chromosome 12q13 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K12 may activate the JNK/SAPK pathway; it is highly expressed in brain and kidney.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
References in periodicals archive ?
CEP-1347 inhibits mixed lineage kinases that activate apoptotic pathways implicated in the pathogenesis of Parkinson's disease.