Classification and diagnostic criteria for mixed connective tissue disease
. In: Mixed Connective Tissue Disease
and Anti-nuclear antibodies, Kasukawa R, Sharp G (Eds), Elsevier, Amsterdam 1987; p.33.
Panniculitis in a patient with mixed connective tissue disease
. Mod Rheumatol.
Clinical usefulness of autoantibodies to U I snRNP proteins in mixed connective tissue disease
and systemic lupus erythematosus.
Pulmonary manifestations of scleroderma and mixed connective tissue disease
. Clin Chest Med.
Fifty-seven (30%) patients had Sjogren syndrome; 50 (26.5%) had systemic lupus erythematosus; 7 (3.7%) had systemic lupus erythematosus and/or Sjogren syndrome; 11 (6%) had subacute cutaneous lupus, discoid lupus, drug-induced lupus, or neonatal lupus; 6 (3%) had mixed connective tissue disease
; 15 (8.5%) had dermatomyositis, scleroderma, rheumatoid arthritis, polymyalgia rheumatica, or undifferentiated systemic disease; and 42 (21.3%) had a medical condition other than a systemic (undifferentiated) rheumatic disease (i.e., not Sjogren syndrome and/or any form of lupus, mixed connective tissue disease
, dermatomyositis, scleroderma, or rheumatoid arthritis).
The commonest disorder was RA seen in 458(76%) patients, followed by SLE in 42(7%), AS in 32(5.3%), mixed connective tissue disease
(MCTD) in 22(3.6%), systemic sclerosis in 12(2%); juvenile RA (JRA) in 7(1.2%), and anti- phospholipid antibodies (APLA) in 6(1%) patients.
Maternal mixed connective tissue disease
and offspring with chondrodysplasia punctata.
Clinicians wondered whether it might be related to the patient's mixed connective tissue disease
; or to a drug, or to both a drug and connective tissue disease.
The chapter on autoimmune disease and serology was not included in the current edition, and related topics such as anti-neutrophil cytoplasmic antibody, anti-nuclear antibody, dermatomyositis, Raynaud disease, and mixed connective tissue disease
were not identified in the index.
Anti-SSA and anti-SSB antibodies are found in Sjogren Syndrome (SS), anti-Sm antibodies are found in systemic lupus erythematosus (SLE), anti-RNP antibodies are found in mixed connective tissue disease
(MCTD), and anti-Scl-70 antibodies are found in scleroderma.