Rye Staging System

(redirected from Mixed cellularity)

Rye Staging System

A system for staging Hodgkin's disease delineated in 1966, which divided it into 4 distinct clinicopathological categories, based on data provided by the then popular method of lymphangiography. Cf Ann Arbor classification, Cotswolds classification.
Rye Classification–Hodgkin's disease
Lymphocytic predominant 10% of cases, more common in young adult ♂, usually early/low-stage disease without 'B' symptoms, 5-year survival: 90%
Nodular sclerosing 40%; more common in young adult ♀, usually early and low-stage disease with or without 'B' symptoms, 5-year survival: 70%
Mixed cellularity 40%; more common in young adult ♂, often stage II-III disease with or without 'B' symptoms, 5-year survival: 50%
Lymphocyte-depleted 10%; more common in older adult ?, usually stage III-IV disease with or without 'B' symptoms, 5-year survival, 30%
References in periodicals archive ?
Of possible aid in their distinction, anaplastic cells in [CD30.sup.+] LPDs vary in size and may have multiple nucleoli, whereas RSCs and their variants are more uniformly large and have 1 or 2 large eosinophilic nucleoli.5 Reed-Sternberg-like cells of [CD30.sup.+] T-LPDs may be set in a polymorphic inflammatory background with eosinophils, neutrophils, plasma cells, and histiocytes similar to mixed cellularity or nodular sclerosis-type CHL.
Mixed Cellularity was the commonest type 31 (62%) followed by Nodular Sclerosis 12 (24%), Immunohistochemical (IHC) staining for EBV antigen was positive in 40 (80%) of cases.
A full-body computed tomography scan revealed a pathologic mediastinal lymph node and biopsy results indicated nodular sclerosing and mixed cellularity Hodgkin's lymphoma.
Subsequently, a diagnosis of a CHL, mixed cellularity subtype was rendered.
There are four histologic subtypes of HD-nodular sclerosing, mixed cellularity, lymphocyte predominance and lymphocyte depletion.
It includes a 10-year epidemiology forecast for the diagnosed incident cases of HL, segmented by age, sex, and clinical stage at diagnosis, and types (classical HL and nodular lymphocyte predominant HL, with classical HL further segmented into subtypes such as nodular sclerosis, mixed cellularity, lymphocyte-rich, and lymphocyte-depleted) in these markets.
Generally, there are four subtypes of CHL; nodular sclerosis, mixed cellularity, lymphocyte-rich, and lymphocyte-depleted.
Classical HL comprises several sub-types such as, nodular sclerosis (NS), mixed cellularity (MC), lymphocyte depletion (LD), and lymphocyte-rich (LR) Hodgkin lymphoma [5].
(fig 9A,B,C,D) Fine needle aspiration cytology of right upper cervical lymph node showed increased cellularity of medium and large lymphocytes having scanty cyto- plasm and was suggestive of Non- Hodgkin's lym- phoma intermediate grade mixed cellularity type.
Histopathology show 66% mixed cellularity variant in Hodgkin's and 37% diffuse B cell pattern in Non Hodgkin's lymphoma.
Among these 19 patients with infiltration 17 (89.4%) patients were of Hodgkin's Ly- mphoma mixed cellularity and 2 (10.5%) had Hodgkin's Lymphoma Nodular Sclerosis.